1-Hydroxy-1-(4-nitrophenyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Hydroxy-1-(4-nitrophenyl)urea
• 英文别名: 1-hydroxy-1-(4-nitrophenyl)urea
• 化学式: C7H7N3O4
• 分子量: 197.15
• InChiKey: XONJZPMMULNKEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US20150368403A1

  公开（公告）日：2015-12-24

  A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
• POLYMERS FOR THERMALLY-REGULATED RELEASE OF HNO AND OTHER MOLECULES
  申请人：University of Washington

  公开号：US20170202874A1

  公开（公告）日：2017-07-20

  Multivalent scaffolds configured to facilitate drug release upon exposure to a stimulus, such as heat, or light, are described herein. The multivalent scaffolds are covalently bound to a moiety that is susceptible to decomposition upon exposure to stimulus. The moiety releases HNO upon decomposition. In some embodiments, the moiety is in turn linked to an agent to be delivered, such as a therapeutic agent, which is released from the multivalent scaffolds when the moiety decomposes. In some embodiments, the moiety is a 1,2-oxazine moiety. In some embodiments, the multivalent scaffold is a polymer. A plurality of 1,2-oxazine moieties can be covalently bound as side chains to the backbone of the polymer.
• US9580553B2
  申请人：——

  公开号：US9580553B2

  公开（公告）日：2017-02-28
• [EN] THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS<br/>[FR] MATÉRIAUX AUTO-IMMOLATEURS THERMO-ACTIVÉS
  申请人：UNIV WASHINGTON CT COMMERCIALI

  公开号：WO2014133620A2

  公开（公告）日：2014-09-04

  A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.