ethyl N-[2-amino-5-[but-2-ynyl-[(4-fluorophenyl)methyl]amino]phenyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl N-[2-amino-5-[but-2-ynyl-[(4-fluorophenyl)methyl]amino]phenyl]carbamate
• 化学式: C₂₀H₂₂FN₃O₂
• 分子量: 355.4
• InChiKey: QDXVSJKQRWZWHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL COMPOUND AS KCNQ POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Shanghai Institute Materia Medica, Chinese Academy Of Sciences

  公开号：EP2772481A1

  公开（公告）日：2014-09-03

  The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereofagonist, preparation methods therefor and a use thereof in the preparation of a medcine for the treatment of nervous system diseases. The compounds or pharmaceutical compositions thereof can be used as the KCNQ potassium channel agonist for treating nervous system diseases. Compared to retigabine, a compound in the prior art, the compound of the present invention have the same or better therapeutic effect, are easier for synthesis and storage, and less prone to oxidate deterioration.

  本发明提供了具有通式 I 所代表结构的化合物、其药学上可接受的盐、其制备方法以及其在制备治疗神经系统疾病的药物中的用途。这些化合物或其药物组合物可用作治疗神经系统疾病的 KCNQ 钾通道激动剂。与现有技术中的化合物瑞替加滨相比，本发明化合物具有相同或更好的治疗效果，更易于合成和储存，不易氧化变质。