10-[(2-Methylpropan-2-yl)oxy]tricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-2-yne

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 10-[(2-Methylpropan-2-yl)oxy]tricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-2-yne
• 英文别名: 10-[(2-methylpropan-2-yl)oxy]tricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-2-yne
• 化学式: C₂₀H₂₀O
• 分子量: 276.4
• InChiKey: WGCDZQZLOFFEJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• CHEMICAL CROSSLINKERS AND COMPOSITIONS THEREOF
  申请人：Nguyen Mark Quang

  公开号：US20140249319A1

  公开（公告）日：2014-09-04

  Chemical crosslinkers and methods of their synthesis are disclosed.

  化学交联剂及其合成方法已被披露。
• CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE
  申请人：NGUYEN MARK QUANG

  公开号：US20140294851A1

  公开（公告）日：2014-10-02

  Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

  揭示了一种含有易碱性交联剂的易碱性共轭物、其合成和使用方法。
• METHODS OF USING CLEAVABLE DRUG CONJUGATES AND COMPOSITIONS THEREOF
  申请人：Nguyen Mark Quang

  公开号：US20160143937A1

  公开（公告）日：2016-05-26

  Methods of synthesizing and using base-labile drug conjugates and compositions thereof are disclosed.

  本发明揭示了合成和使用碱性不稳定药物结合物及其组合物的方法。
• Sustained release delivery systems comprising traceless linkers
  申请人：NOVARTIS AG

  公开号：US10751417B2

  公开（公告）日：2020-08-25

  Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

  本文描述了用于递送生物活性制剂的药物递送系统，该系统包含伯胺或仲胺或杂杂芳环的环氮原子、其药学上可接受的盐、与之相关的药物递送试剂、包含该药物递送系统的药物组合物，以及该药物递送系统作为缓释治疗剂的用途。
• OPTIMIZED TRANSGLUTAMINASE SITE-SPECIFIC ANTIBODY CONJUGATION
  申请人：REGENERON PHARMACEUTICALS, INC.

  公开号：US20190070306A1

  公开（公告）日：2019-03-07

  Provided herein are methods and compositions for site-specific conjugation of antibodies in the presence of a transglutaminase.