N-甲基中卟啉IX | 142234-85-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 中文名称: N-甲基中卟啉IX
• 中文别名: N-甲基卟啉二丙酸 IX
• 英文名称: N-methyl mesoporphyrin IX
• 英文别名: 3-[18-(2-carboxyethyl)-7,12-diethyl-3,8,13,17,22-pentamethyl-23H-porphyrin-2-yl]propanoic acid
• CAS: 142234-85-3
• 化学式: C₃₅H₄₀N₄O₄
• 分子量: 580.7
• InChiKey: XODZICXILWCPBD-UHFFFAOYSA-N

物化性质

• 密度：
  1.26±0.1 g/cm3(Predicted)
• 溶解度：
  DMF：20mg/mL； DMF:PBS (pH 7.2) (1:5)：0.17 mg/mL；二甲基亚砜：15mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• FORMULATIONS AND USES FOR MICROPARTICLE DELIVERY OF METALLOPORPHYRINS
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20170035778A1

  公开（公告）日：2017-02-09

  Formulations and methods of use thereof that relate to biocompatible delivery of stabilized porphyrin complexes are provided. Formulations may include microparticles comprising the porphyrin complex, wherein the porphyrin active agent is admixed or coated with a pharmaceutically acceptable stabilizer.
• [EN] FORMULATIONS AND USES FOR MICROPARTICLE DELIVERY OF METALLOPORPHYRINS<br/>[FR] FORMULATIONS ET UTILISATIONS RELATIVES À L'ADMINISTRATION DE MÉTALLOPORPHYRINES EN MICROPARTICULES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2017023970A1

  公开（公告）日：2017-02-09

  Formulations and methods of use thereof that relate to biocompatible delivery of stabilized porphyrin complexes are provided. Formulations may include microparticles comprising the porphyrin complex, wherein the porphyrin active agent is admixed or coated with a pharmaceutically acceptable stabilizer.
• [EN] METALLOPORPHYRIN MICROPARTICLES FOR TREATMENT OF ANEMIA AND TROPICAL DISEASES<br/>[FR] MICROPARTICULES DE MÉTALLOPORPHYRINES POUR LE TRAITEMENT DE L'ANÉMIE ET DE MALADIES TROPICALES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2018144845A1

  公开（公告）日：2018-08-09

  Methods of use for reducing the serum iron concentration to treatment of various conditions using a composition comprising microparticles comprising a metal porphyrin complex and a pharmaceutically acceptable stabilizer are disclosed.