1-[4-[2-[Bis(4-fluorophenyl)methylsulfinyl]ethyl]piperazin-1-yl]-1-phenylpropan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-[2-[Bis(4-fluorophenyl)methylsulfinyl]ethyl]piperazin-1-yl]-1-phenylpropan-2-ol
• 英文别名: 1-[4-[2-[bis(4-fluorophenyl)methylsulfinyl]ethyl]piperazin-1-yl]-1-phenylpropan-2-ol
• 化学式: C₂₈H₃₂F₂N₂O₂S
• 分子量: 498.6
• InChiKey: PLAQNDFTUZXTOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF
  申请人：The United States of America, as represented by The Secretary, Department of Health and Human Services

  公开号：EP2964611A2

  公开（公告）日：2016-01-13
• [EN] POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF<br/>[FR] INHIBITEURS PUISSANTS ET SÉLECTIFS DE TRANSPORTEURS DE MONOAMINE; PROCÉDÉ DE FABRICATION; ET LEUR UTILISATION
  申请人：US HEALTH

  公开号：WO2014138518A2

  公开（公告）日：2014-09-12

  Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.