(2,2-Dimethylpyrrolidin-1-yl) 2,2-dimethyl-4-nitrooxybutanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2,2-Dimethylpyrrolidin-1-yl) 2,2-dimethyl-4-nitrooxybutanoate
• 英文别名: (2,2-dimethylpyrrolidin-1-yl) 2,2-dimethyl-4-nitrooxybutanoate
• 化学式: C12H22N2O5
• 分子量: 274.31
• InChiKey: PYAPMYVWXDXMPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  84.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PRODRUGS OF MULTIFUNCTIONAL NITROXIDE DERIVATIVES AND USES THEREOF
  申请人：Radikal Therapeutics Inc.

  公开号：EP2964218A2

  公开（公告）日：2016-01-13
• METHOD FOR TREATING DISEASES ASSOCIATED WITH OXIDATIVE STRESS OR ENDOTHELIAL DYSFUNCTION
  申请人：RADIKAL THERAPEUTICS INC.

  公开号：US20170327466A1

  公开（公告）日：2017-11-16

  A method reduces oxidative stress or endothelial dysfunction in a mammal. The method includes administering to the mammal a compound of formula I: or an enantiomer, diastereomer, racemate, or a pharmaceutically acceptable salt of the compound.
• [EN] PRODRUGS OF MULTIFUNCTIONAL NITROXIDE DERIVATIVES AND USES THEREOF<br/>[FR] PROMÉDICAMENTS DE DÉRIVÉS D'OXYDES D'AZOTE MULTIFONCTIONNELS ET LEURS UTILISATIONS
  申请人：RADIKAL THERAPEUTICS INC

  公开号：WO2014136059A2

  公开（公告）日：2014-09-12

  The invention provides prodrugs of compounds comprising a nitric oxide donor and a reactive oxygen species (ROS) degradation catalyst, in particular, 1-pyrrolidinyloxy, 1- piperidinyloxy, and 1-azepanyloxy derivatives, and pharmaceutical compositions thereof. These compounds and pharmaceutical compositions are useful in prevention, treatment or management of diseases, disorders or conditions associated with oxidative stress or endothelial dysfunction.