3.3a.8.8a-Tetrahydrocyclopentniden-1<2H>on | 24499-29-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 3.3a.8.8a-Tetrahydrocyclopentniden-1<2H>on
• 英文别名: 3,8-dihydro-2H-cyclopent[a]inden-1-one；3,8-Dihydro-2H-cyclopent[a]inden-1-on；3,8-dihydrocyclopent[a]inden-1[2H]-one；2,4-dihydro-1H-cyclopenta[a]inden-3-one
• CAS: 24499-29-4
• 化学式: C₁₂H₁₀O
• 分子量: 170.211
• InChiKey: JXKVRYBOCCMORC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

上下游信息

反应信息

• 作为反应物：
  描述：

  3.3a.8.8a-Tetrahydrocyclopentniden-1<2H>on 在 氢气 作用下， 以 palladium on charcoal 、 乙醇 为溶剂， 生成 3,3a,8,8a-Tetrahydro-cyclopent[a]inden-1[2H]-one
  参考文献：
  名称：

  Cyclopent [a] indene compounds

  摘要：

  通式（I）的印第安衍生物：##SPC1## 其中：R.sub.1和R.sub.2代表氢原子，较低的烷基，优选含1至6个特别是1至4个碳原子的烷基或芳基烷基，或者一起形成含3-6个碳原子的环烷基；R.sub.3是氢原子或较低的烷基，优选含1至6个特别是1至4个碳原子；R.sub.4代表--NR.sub.5 R.sub.6基团，其中R.sub.5和R.sub.6可以相同或不同，并且每个代表氢原子，氨基甲酰基或较低的烷基基团，优选含1至6个特别是1至4个碳原子，可以选择地被氨基，烷基氨基，二烷基氨基，羟基，芳基或芳香基取代，其中芳香基可以被取代；或其中R.sub.5和R.sub.6可以连接以形成可选地含有其他杂原子的环；以及其无毒药学上可接受的盐和酯。这些化合物具有显著的镇痛活性，并且不具有呼吸抑制作用。

  公开号：

  US03952050A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 四氯化锡 、 苯 作用下， 生成 3.3a.8.8a-Tetrahydrocyclopentniden-1<2H>on
  参考文献：
  名称：

  Clemo et al., Journal of the Chemical Society, 1951, p. 863,865

  摘要：

  DOI：

文献信息

• INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：Alcalde-Pais Maria De Las Ermitas

  公开号：US20090163547A1

  公开（公告）日：2009-06-25

  The present invention makes reference to new indene derivatives with general formula (I), as well as to their preparation procedures, their application as medicament and the pharmaceutical compositions containing them. The new compounds of formula (I) show affinity for 5-HT 6 receptors and are, therefore, effective for treating diseases mediated by these receptors.

  本发明涉及一种新的茚烯衍生物，其通式为（I），以及它们的制备方法、作为药物的应用和含有它们的药物组合物。公式（I）的新化合物显示出对5-HT6受体的亲和力，因此对于治疗由这些受体介导的疾病是有效的。
• Indene derivatives, their preparation and use as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP2202222A2

  公开（公告）日：2010-06-30

  The present invention makes reference to new indene derivatives with general formula (I), as well as to their preparation procedures, their application as medicament and the pharmaceutical compositions containing them. The new compounds of formula I show affinity for 5-HT6 receptors and are, therefore, effective for treating diseases mediated by these receptors.

  本发明涉及通式（I）的新茚衍生物，以及它们的制备程序、作为药物的应用和含有它们的药物组合物。式 I 的新化合物显示出对 5-HT6 受体的亲和力，因此可有效治疗由这些受体介导的疾病。
• Posthysterectomy Vault Eversion with a Large Retroperitoneal Mass
  作者：V. L. Handa、K. Jain、K. McCue、P. D. Schneider

  DOI：10.1007/pl00004038

  日期：2001.8

  A woman with complete vaginal eversion was found to have a large pelvic mass, extending from the rectovaginal septum to the presacral space. This 66-year-old woman with posthysterectomy vaginal eversion complained of pelvic fullness. A pessary provided relief of the prolapse, but the symptom of fullness persisted. Physical examination did not identify a pelvic mass. Computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated a 9 cm tumor of the rectovaginal septum, extending to the presacral space. At laparotomy the patient had a massive neurofibroma arising from the anterior rectal wall. This case is of interest because the complete vaginal prolapse obscured the diagnosis of this large pelvic tumor. CT and MRI were useful in identifying and characterizing the mass. To our knowledge, this is the first reported case of vaginal prolapse with a large pelvic mass.
• Stereoselective Reduction of α,β-Unsaturated Ketones with Raney-Nickel Alloy
  作者：N. F. HAYES

  DOI：10.1055/s-1975-23891

  日期：——
• US8217041B2
  申请人：——

  公开号：US8217041B2

  公开（公告）日：2012-07-10