4,4-Dimethyl-3-propan-2-yl-1,3-oxazolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4,4-Dimethyl-3-propan-2-yl-1,3-oxazolidine
• 英文别名: 4,4-dimethyl-3-propan-2-yl-1,3-oxazolidine
• 化学式: C₈H₁₇NO
• 分子量: 143.23
• InChiKey: PQJXECWBCOEHIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• US20140256700A1
  申请人：——

  公开号：US20140256700A1

  公开（公告）日：2014-09-11
• TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170273965A1

  公开（公告）日：2017-09-28

  The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
• US9492460B2
  申请人：——

  公开号：US9492460B2

  公开（公告）日：2016-11-15