Bicyclo[2.2.0]hexa-1(4),2,5-triene;sulfamic acid

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: Bicyclo[2.2.0]hexa-1(4),2,5-triene;sulfamic acid
• 英文别名: bicyclo[2.2.0]hexa-1(4),2,5-triene;sulfamic acid
• 化学式: C6H7NO3S
• 分子量: 173.19
• InChiKey: GHCABFUPRBSJHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.03
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES<br/>[FR] COMPOSITIONS, FORMULATIONS ET MÉTHODES DE TRAITEMENT DE MALADIES OCULAIRES
  申请人：AERPIO THERAPEUTICS INC

  公开号：WO2014145068A1

  公开（公告）日：2014-09-18

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.

  本文披露了一些能够激活Tie-2并抑制HPTP-beta的化合物。这些化合物可以为与血管生成相关的疾病，例如眼部疾病，提供有效的治疗。还披露了增加溶解度的配方。同时也披露了与抗体的联合治疗以及PK/PD数据。
• [EN] SMALL MOLECULE ACTIVATORS OF TIE-2<br/>[FR] ACTIVATEURS À PETITES MOLÉCULES DE TIE-2
  申请人：AERPIO PHARMACEUTICALS INC

  公开号：WO2021086904A1

  公开（公告）日：2021-05-06

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for vascular disorders that can include, for example, retinopathies, ocular edema, and ocular neovascularization.

  本公开涉及的化合物对激活Tie-2和抑制HPTP-beta有效。这些化合物可以为血管疾病提供有效的治疗，例如视网膜病变、眼部水肿和眼部新生血管。
• HPTP-BETA INHIBITORS
  申请人：Aerpio Therapeutics Inc.

  公开号：US20150259335A1

  公开（公告）日：2015-09-17

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed.

  本文披露了对Tie-2激活和HPTP-beta抑制有效的化合物。这些化合物可以为与血管生成有关的疾病提供有效的治疗，例如眼部疾病。还披露了增加溶解度的配方。
• COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES
  申请人：Aerpio Therapeutics, Inc.

  公开号：US20160220540A1

  公开（公告）日：2016-08-04

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.

  本文披露了一些有效激活Tie-2并抑制HPTP-beta的化合物。这些化合物可以为与血管生成有关的疾病，例如眼部疾病提供有效的治疗。本文还披露了增加溶解度的配方。同时，本文还披露了抗体的联合疗法和PK/PD数据。
• HPTP-Beta inhibitors
  申请人：Aerpio Pharmaceuticals, Inc.

  公开号：US10858354B2

  公开（公告）日：2020-12-08

  Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed.

  本文公开了对激活 Tie-2 和抑制 HPTP-beta 有效的化合物。这些化合物可有效治疗与血管生成有关的疾病，例如眼部疾病。还公开了可提高溶解度的制剂。