1-(2-Carbamoyl-5-formylphenyl)-2,5-dioxopyrrolidine-3-sulfonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Carbamoyl-5-formylphenyl)-2,5-dioxopyrrolidine-3-sulfonic acid
• 英文别名: 1-(2-carbamoyl-5-formylphenyl)-2,5-dioxopyrrolidine-3-sulfonic acid
• 化学式: C₁₂H₁₀N₂O₇S
• 分子量: 326.28
• InChiKey: UNIDGYRKABJHAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  160
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• V3 IMMUNOGENS
  申请人：DUKE UNIVERSITY

  公开号：US20160106827A1

  公开（公告）日：2016-04-21

  The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and using same.

  本发明涉及人类免疫缺陷病毒（HIV），特别是涉及一种HIV-1疫苗，包括合成的V3糖肽，并涉及其制备和使用方法。
• Calibrating single plasmonic nanostructures for quantitative biosening
  申请人：Raphael Marc P.

  公开号：US10345287B2

  公开（公告）日：2019-07-09

  A method for calibrating multiple nanostructures in parallel for quantitative biosensing using a chip for localized surface plasmon resonance (LSPR) biosensing and imaging. The chip is a glass coverslip compatible for use in a standard microscope with at least one array of functionalized plasmonic nanostructures patterned onto it using electron beam nanolithography. The chip is used to collect CCD-based LSPR imagery data of each individual nanostructure and LSPR spectral data of the array. The spectral data is used to determine the fractional occupancy of the array. The imagery data is modeled as a function of fractional occupancy to determine the fractional occupancy of each individual nanostructure.

  一种利用局部表面等离子体共振（LSPR）生物传感和成像芯片并行校准多个纳米结构以进行定量生物传感的方法。该芯片是一种可在标准显微镜中使用的玻璃盖玻片，上面至少有一个使用电子束纳米光刻技术图案化的功能化等离子体纳米结构阵列。该芯片用于收集每个单独纳米结构的基于 CCD 的 LSPR 图像数据和阵列的 LSPR 光谱数据。光谱数据用于确定阵列的占用率。图像数据被建模为分数占有率的函数，以确定每个单独纳米结构的分数占有率。
• Cyclic HIV-1 Env V3 glycopeptide immunogens
  申请人：DUKE UNIVERSITY

  公开号：US10286057B2

  公开（公告）日：2019-05-14

  The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and using same.

  本发明总体上涉及人类免疫缺陷病毒（HIV），特别是涉及由合成 V3 糖肽组成的 HIV-1 疫苗，以及制造和使用该疫苗的方法。
• Nanoplasmonic imaging technique for the spatio-temporal mapping of single cell secretions in real time
  申请人：The Government of the United States of America, as represented by the Secretary of the Navy

  公开号：US10641705B2

  公开（公告）日：2020-05-05

  A label-free method for the spatio-temporal mapping of protein secretions from individual cells in real time by using a chip for localized surface plasmon resonance (LSPR) imaging. The chip is a glass coverslip compatible for use in a standard microscope having at least one array of functionalized plasmonic nanostructures patterned onto it. After placing a cell on the chip, the secretions from the cell are spatially and temporally mapped using LSPR imaging. Transmitted light imaging and/or fluorescence imaging may be done simultaneously with the LSPR imaging.

  利用局部表面等离子体共振（LSPR）成像芯片实时绘制单个细胞蛋白质分泌时空图的无标记方法。这种芯片是一种可用于标准显微镜的玻璃盖玻片，上面至少有一个功能化等离子体纳米结构阵列。将细胞放在芯片上后，利用 LSPR 成像技术对细胞的分泌物进行空间和时间映射。透射光成像和/或荧光成像可与 LSPR 成像同时进行。
• Determining extracellular analyte concentration with nanoplasmonic sensors
  申请人：The Government of the United States of America, as represented by the Secretary of the Navy

  公开号：US10761028B2

  公开（公告）日：2020-09-01

  Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components.

  本文公开了确定分析物细胞外浓度数据的方法和系统。一种确定分析物的细胞外浓度数据的方法包括接收来自与含有至少一个活细胞的流体接触多次的局部表面等离子体共振成像芯片上的一个或多个功能化等离子体纳米结构阵列的传感器数据，确定一个或多个阵列的强度数据，基于强度数据确定分占率，以及基于分占率数据确定细胞外浓度数据。用于确定分析物的细胞外浓度数据的系统包括 LSPRi 芯片、传感器组件、强度组件、部分占据组件、浓度组件和用于实现这些组件的处理器。