N-[1-(5-fluoro-2-methoxy-phenyl)-ethyl]-2-[4-(5-isobutyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide | 35253-24-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[1-(5-fluoro-2-methoxy-phenyl)-ethyl]-2-[4-(5-isobutyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
• 英文别名: N-(1-(5-Fluoro-2-methoxyphenyl)ethyl)-4-(((5-(2-methylpropyl)-2-pyrimidinyl)amino)sulfonyl)ben zeneacetamide；N-[1-(5-fluoro-2-methoxyphenyl)ethyl]-2-[4-[[5-(2-methylpropyl)pyrimidin-2-yl]sulfamoyl]phenyl]acetamide
• CAS: 35253-24-8
• 化学式: C₂₅H₂₉FN₄O₄S
• 分子量: 500.594
• InChiKey: CKOLETHYECDWSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-[4-[[5-(2-methylpropyl)pyrimidin-2-yl]sulfamoyl]phenyl]acetyl chloride;hydrochloride 、 1-(5-Fluor-2-methoxyphenyl)aethylamin 生成 N-[1-(5-fluoro-2-methoxy-phenyl)-ethyl]-2-[4-(5-isobutyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
  参考文献：
  名称：

  RUFER, C.;AHRENS, H.;BIERE, H.;SCHROEDER, E.;GERHARDS, E.;LOSERT, W. F.

  摘要：

  DOI：

文献信息

• RUFER, C.;AHRENS, H.;BIERE, H.;SCHROEDER, E.;GERHARDS, E.;LOSERT, W. F.
  作者：RUFER, C.、AHRENS, H.、BIERE, H.、SCHROEDER, E.、GERHARDS, E.、LOSERT, W. F.

  DOI：——

  日期：——
• Extract Formulations of Rhodamnia Cinerea And Uses Thereof
  申请人：Gehling Matthias

  公开号：US20150050371A1

  公开（公告）日：2015-02-19

  The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.
• [EN] EXTRACT FORMULATIONS OF RHODAMNIA CINEREA AND USES THEREOF<br/>[FR] FORMULATIONS EXTRAITES DE RHODAMNIA CINEREA ET UTILISATIONS CORRESPONDANTES
  申请人：BIOTROPICS MALAYSIA BERHAD

  公开号：WO2013133685A1

  公开（公告）日：2013-09-12

  The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.