(2-Oxoazetidin-3-yl)-undec-10-ynylcarbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (2-Oxoazetidin-3-yl)-undec-10-ynylcarbamic acid
• 英文别名: (2-oxoazetidin-3-yl)-undec-10-ynylcarbamic acid
• 化学式: C₁₅H₂₄N₂O₃
• 分子量: 280.36
• InChiKey: KSSASSHRAIHYMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• MODULATION OF N-ACYLETHANOLAMINE-HYDROLYSING ACID AMIDASE (NAAA) FOR DISEASE TREATMENT
  申请人：FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：US20190135802A1

  公开（公告）日：2019-05-09

  Pharmaceutical compositions make up a compound acting as inhibitor of N-acylethanolamine-hydrolysing acid amidase (NAAA), may be used for the therapeutical treatment and prevention of pain and inflammatory disorders and other disorders which benefit from the modulation of fatty acid ethanolamines, particularly palmitoylethanolamide (PEA). The compound is used in methods of inhibiting NAAA and methods of therapeutical treatment and prevention of pain and inflammation.

  药物组合物构成一种作为N-酰乙醇胺水解酸酶（NAAA）抑制剂的化合物，可用于治疗和预防疼痛和炎症性疾病以及其他受益于脂肪酸乙醇胺调节的疾病，特别是棕榈酰乙醇胺（PEA）。该化合物用于抑制NAAA的方法以及治疗和预防疼痛和炎症的方法。
• Modulation of N-acylethanolamine-hydrolysing acid amidase (NAAA) for disease treatment
  申请人：FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：US10364242B2

  公开（公告）日：2019-07-30

  Pharmaceutical compositions make up a compound acting as inhibitor of N-acylethanolamine-hydrolyzing acid amidase (NAAA), may be used for the therapeutical treatment and prevention of pain and inflammatory disorders and other disorders which benefit from the modulation of fatty acid ethanolamines, particularly palmitoylethanolamide (PEA). The compound is used in methods of inhibiting NAAA and methods of therapeutical treatment and prevention of pain and inflammation.

  由一种作为 N-乙酰乙醇胺-水解酸酰胺酶（NAAA）抑制剂的化合物组成的药物组合物，可用于治疗和预防疼痛、炎症性疾病和其他从调节脂肪酸乙醇胺，特别是棕榈酰乙醇胺（PEA）中获益的疾病。该化合物可用于抑制 NAAA 的方法以及治疗和预防疼痛和炎症的方法。
• [EN] CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS<br/>[FR] DÉRIVÉS DE CARBAMATE D'INHIBITEURS D'AMIDASE ACIDE DE N-ACYLÉTHANOLAMINE (NAAA) À BASE DE LACTAME
  申请人：UNIV CALIFORNIA

  公开号：WO2014144836A2

  公开（公告）日：2014-09-18

  Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.