1,2-difluoroanthraquinone | 23041-77-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,2-difluoroanthraquinone
• 英文别名: 1,2-difluoroanthracene-9,10-dione；1,2-Difluor-anthrachinon
• CAS: 23041-77-2
• 化学式: C₁₄H₆F₂O₂
• 分子量: 244.197
• InChiKey: RGALIJDPFBKIGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-二氟溴苯 、 3-氰苯酞 在 lithium diisopropyl amide 作用下， 生成 1,2-difluoroanthraquinone
  参考文献：
  名称：

  Synthesis of fluorine-substituted anthraquinones and aza-anthraquinones

  摘要：

  Using 1,4-dipolar-aryne cycloaddition methodology, a convenient, short synthesis of several fluoroanthraquinones is presented which involves the reaction of haloarenes and 3-cyanophthalides in the presence of lithium diisopropylamide (LDA) in tetrahydrofuran (THF). The fluorine substituent(s) can be introduced by using fluorine-substituted haloarenes and/or 3-cyanophthalides. Similarly, fluorine-substituted pyridines can be prepared by treating fluorine-substituted cyanophthalides and halopyridines in the presence of lithium diisopropylamide.

  DOI：

  10.1016/0022-1139(93)03030-p

文献信息

• [EN] BH4 ANTAGONISTS AND METHODS RELATED THERETO<br/>[FR] ANTAGONISTES DE BH4 ET PROCÉDÉS ASSOCIÉS À CEUX-CI
  申请人：UNIV EMORY

  公开号：WO2015171589A1

  公开（公告）日：2015-11-12

  The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

  该公开涉及BH4抑制剂及其治疗用途。在某些实施方式中，该公开涉及治疗或预防癌症的方法，例如肺癌，包括向需要的受试者施用本公开的化合物或药学上可接受的盐组成的药物组合物的治疗有效量。
• Fluorochromes for organelle tracing and multi-color imaging
  申请人：Patton Wayne Forrest

  公开号：US20100062429A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和试剂盒，用于鉴定感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，用于确定细胞器的位置、数量，甚至用于区分感兴趣的细胞中的细胞器。
• Method of Coloring Hair with Direct Dye Compounds
  申请人：The Procter & Gamble Company

  公开号：US20160271042A1

  公开（公告）日：2016-09-22

  Described herein is a method of dyeing the hair. The method includes applying to the hair a hair color composition including one or more direct dye compounds and rinsing the hair with water. The one or more direct dye compounds each include a chromophore, one or two permanent cations, and one to four incipient cations. The one to four incipient cations are pendant to the core structure and are neutral. The one or more direct dye compounds enter the hair shaft after the hair color composition is applied to the hair. The hair color composition has a pH of from about 7 to about 11. The pH of the hair after rinsing is from about 3.5 to about 6. The rinsing of the hair causes one or more of the one to four incipient cations to change from neutral to positively charged inside of the hair shaft.

  本文描述了一种染发的方法。该方法包括将含有一种或多种直接染料化合物的染发剂涂抹于头发上，并用水冲洗头发。这些一种或多种直接染料化合物每种都包括色团、一个或两个永久阳离子和一个到四个潜阳离子。这些一到四个潜阳离子是悬挂在核心结构上的中性离子。在将染发剂涂抹于头发后，这些一种或多种直接染料化合物进入了头发内部。染发剂的pH值在约7至11之间。冲洗头发后，头发的pH值在约3.5至6之间。冲洗头发会导致其中一个或多个潜阳离子在头发内部从中性变为带正电荷。
• Compositions for Dyeing Hair with Cationic Direct Dyes
  申请人：The Procter & Gamble Company

  公开号：US20160271030A1

  公开（公告）日：2016-09-22

  Described herein is a hair color composition for dyeing the hair. The hair color composition includes one or more direct dye compounds and one or more additional ingredients. The one or more direct dye compounds each include a chromophore, one or two permanent cations, and one to four incipient cations. The one to four incipient cations are pendant to the core structure and are neutral. The one or more direct dye compounds enter the hair shaft after the hair color composition is applied to the hair. The hair color composition has a pH of from about 7 to about 11.

  以下是染发用的一种发色配方。该发色配方包括一种或多种直接染料化合物和一种或多种额外成分。其中，每种直接染料化合物包括一个色团、一个或两个永久阳离子以及一个到四个初级阳离子。这一到四个初级阳离子悬挂于核心结构上，是中性的。在该发色配方被涂抹到头发上后，这一种或多种直接染料化合物会进入发丝内部。该发色配方的pH值在约7到约11之间。
• Novel fluorochromes for organelle tracing and multi-color imaging
  申请人：Pande Praveen

  公开号：US20100062460A1

  公开（公告）日：2010-03-11

  Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.

  提供了一些化合物、方法和工具包，用于识别感兴趣的细胞中的细胞器，包括细胞核和各种非细胞核细胞器，以及细胞区域或细胞域。这些化合物和方法可以与其他常规检测试剂一起使用，以识别感兴趣细胞中细胞器的位置、位置或数量，甚至用于区分细胞器。