BG-PEG-NH2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: BG-PEG-NH2
• 英文别名: 1-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-3-[[4-[(2-amino-7H-purin-6-yl)oxymethyl]phenyl]methyl]urea
• 化学式: C₂₂H₃₂N₈O₅
• 分子量: 488.547
• InChiKey: AMXSINWJQXAFOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  35
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  185
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  BG-PEG-NH2 、 halotag O4 succinimidyl ester 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 BG-HALO
  参考文献：
  名称：

  [EN] LASERTAG: A TOOLKIT ALLOWING THE SPACE-SPECIFIC RECOVERY, CONTROL AND MODIFICATION OF SINGLE CELLS AND BIOLOGICAL MOLECULES IN VIVO
  [FR] MARQUEUR LASER: BOÎTE À OUTILS PERMETTANT LA RÉCUPÉRATION, LE CONTRÔLE ET LA MODIFICATION SPÉCIFIQUES À L'ESPACE DE CELLULES UNIQUES ET DE MOLÉCULES BIOLOGIQUES IN VIVO

  摘要：

  在某些方面，该披需涉及与光遮蔽分子偶联的自锁蛋白标签以及它们的使用方法。

  公开号：

  WO2016081769A1

文献信息

• Multiplex immuno screening assay
  申请人：Institut Pasteur

  公开号：US10209248B2

  公开（公告）日：2019-02-19

  The present invention provides an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and oriented coupling of fusion proteins comprising an AGT enzyme and a viral antigen on an identifiable solid support (e.g. fluorescent microspheres). The thus obtained antigen-coupled microspheres show enhanced capture of specific antibodies as compared to antigen-coupled microspheres produced by standard amine coupling procedures.

  本发明提供了一种免疫测定方法，可快速、同时检测受感染病人生物液体中多种传染性病原体的抗体。这种免疫测定方法是将由 AGT 酶和病毒抗原组成的融合蛋白共价定向偶联在可识别的固体支持物（如荧光微球）上。与通过标准胺偶联程序生产的抗原偶联微球相比，由此获得的抗原偶联微球对特异性抗体的捕获能力更强。
• Specific photoimmuno-theranostics for detection and elimination of skin cancer cells
  申请人：University of Cape Town

  公开号：US11124574B2

  公开（公告）日：2021-09-21

  The technology provided herein generally relates to novel specific photoimmuno-theranostics for the use in detection and elimination of skin cancer cells. The technology also relates to novel methods which generate homogeneous and specific photoimmuno-theranostics reagents in a simple, controlled and efficient way. This method combines molecular optical imaging, photodynamic therapy and immunotherapy using SNAP-tag technology.

  本文提供的技术一般涉及用于检测和消除皮肤癌细胞的新型特异性光免疫共振试剂。该技术还涉及以简单、可控和高效的方式生成同质特异性光免疫疗法试剂的新方法。这种方法利用 SNAP 标记技术将分子光学成像、光动力疗法和免疫疗法结合在一起。
• US20140274762A1
  申请人：——

  公开号：US20140274762A1

  公开（公告）日：2014-09-18
• Multiplex Immuno Screening Assay
  申请人：Institut Pasteur

  公开号：US20150099656A1

  公开（公告）日：2015-04-09

  The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and oriented coupling of fusion proteins comprising an AGT enzyme and a viral antigen on an identifiable solid support (e.g. fluorescent microspheres), said support being previously coated with an AGT substrate. This coupling is mediated by the irreversible reaction of the AGT enzyme on its substrate. The thus obtained antigen-coupled microspheres show enhanced capture of specific antibodies as compared to antigen-coupled microspheres produced by standard amine coupling procedures. The methods of the invention possess the ability to multiplex, minimize the amount of biological sample, and have enhanced sensitivity and specificity toward target antibodies as compared with classical ELISA or Radio-Immunoprecipitation assays.
• MULTIPLEX IMMUNO SCREENING ASSAY
  申请人：INSTITUT PASTEUR

  公开号：US20170276672A1

  公开（公告）日：2017-09-28

  The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the present invention discloses an immunoassay leading to the rapid and simultaneous detection of antibodies to a wide range of infectious pathogens in biological fluids of infected patients. This immunoassay involves the covalent and oriented coupling of fusion proteins comprising an AGT enzyme and a viral antigen on an identifiable solid support (e.g. fluorescent microspheres), said support being previously coated with an AGT substrate. This coupling is mediated by the irreversible reaction of the AGT enzyme on its substrate. The thus obtained antigen-coupled microspheres show enhanced capture of specific antibodies as compared to antigen-coupled microspheres produced by standard amine coupling procedures. The methods of the invention possess the ability to multiplex, minimize the amount of biological sample, and have enhanced sensitivity and specificity toward target antibodies as compared with classical ELISA or Radio-Immunoprecipitation assays.