2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-dimethylphenyl)phosphino]butane | 71359-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-dimethylphenyl)phosphino]butane
• 英文别名: (R,R)-O-Isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-dimethylphenyl)phosphino]butane；[5-[bis(3,5-dimethylphenyl)phosphanylmethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methyl-bis(3,5-dimethylphenyl)phosphane
• CAS: 71359-96-1
• 化学式: C₃₉H₄₈O₂P₂
• 分子量: 610.756
• InChiKey: PWIPOKNGHOZGIG-UHFFFAOYSA-N

物化性质

• 沸点：
  706.3±60.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] HYDROFORMYLATION PROCESS<br/>[FR] PROCÉDÉ D'HYDROFORMYLATION
  申请人：LYONDELL CHEMICAL TECH LP

  公开号：WO2010132087A1

  公开（公告）日：2010-11-18

  A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst comprising a rhodium complex and a diphosphine. The diphoshine is a trans-1,2-bis(bis(3,4-di-n-alkylphenyl)phosphinomethyl)cyclobutane and/or a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,4-di-n-alkylphenyl)phosphino] butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.

  本发明涉及一种生产4-羟基丁醛的方法。该方法包括在溶剂和催化剂的存在下，将丙烯醇与一种一氧化碳和氢气的混合物反应，所述催化剂包括一个铑配合物和一个二膦。所述二膦是一种trans-1,2-双[双(3,4-二-n-烷基苯基)膦甲基]环丁烷和/或2,3-O-异丙亚甲基-2,3-双羟基-1,4-双[双(3,4-二-n-烷基苯基)膦基]丁烷。与3-羟基-2-甲基丙醛相比，该方法可高产4-羟基丁醛。
• High linear selectivity ligand for allyl alcohol hydroformylation
  申请人：Lyondell Chemical Technology, L.P.

  公开号：US10807934B1

  公开（公告）日：2020-10-20

  A process for selectively producing 4-hydroxybutyraldehyde from allyl alcohol is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a trans-1,2-bis(bis(3,4,5-tri-n-alkylphenyl)phosphinomethyl)-cyclobutane. The process gives high yield of 4-hydroxybutyraldehyde compared to temperature.

  本发明描述了一种从丙烯醇选择性地生产4-羟基丁醛的过程。该过程包括在溶剂和催化剂体系的存在下，将丙烯醇与一种混合物（包括一氧化碳和氢气）反应，所述催化剂体系包括一个铑配合物和一个trans-1,2-双（双（3,4,5-三-n-烷基苯基）磷酰甲基）环丁烷。与温度相比，该过程可以高产得4-羟基丁醛。
• RUTHENIUM COMPOUND AND METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALCOHOL COMPOUND
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2264000A1

  公开（公告）日：2010-12-22

  A novel ruthenium compound that is useful as an asymmetric reduction catalyst for carbonyl compounds. The ruthenium compound of the present invention is represented by a formula (I): (Ru(X)2(Pxx)[R1R2C(NH2)-R3R4C(NH2)] (I)), and when this compound is used as an asymmetric reduction catalyst, an optically active aminoalcohol compound can be produced from an a-aminoketone, and particularly a compound represented by formula (IV), with high stereoselectivity and high yield.

  一种可用作羰基化合物不对称还原催化剂的新型钌化合物。本发明的钌化合物由式（I）表示：(Ru(X)2(Pxx)[R1R2C(NH2)-R3R4C(NH2)](I))，当该化合物用作不对称还原催化剂时，可以高立体选择性和高产率从a-氨基酮制得光学活性氨基醇化合物，特别是由式(IV)表示的化合物。
• Bis-phosphin-Metallkomplexe, Verfahren zu ihrer Herstellung, Hydrierungskatalysatoren aus diesen Komplexen und Hydrierungsverfahren unter Verwendung dieser Katalysatoren
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0000403B1

  公开（公告）日：1981-06-17
• HYDROFORMYLATION PROCESS
  申请人：Lyondell Chemical Technology, L.P.

  公开号：EP2081882B1

  公开（公告）日：2012-07-25