Sulfanyl 5-ethylsulfanyl-4-methyl-5-sulfanylidenepentanoate

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: Sulfanyl 5-ethylsulfanyl-4-methyl-5-sulfanylidenepentanoate
• 英文别名: sulfanyl 5-ethylsulfanyl-4-methyl-5-sulfanylidenepentanoate
• 化学式: C₈H₁₄O₂S₃
• 分子量: 238.4
• InChiKey: VFEOWDTWUSMNHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS FOR CONTROLLED LOCALIZED DELIVERY OF BONE FORMING THERAPEUTIC AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR L'ADMINISTRATION LOCALISÉE COMMANDÉE D'AGENTS THÉRAPEUTIQUES POUR LA FORMATION OSSEUSE
  申请人：UNIV ROCHESTER

  公开号：WO2014152451A2

  公开（公告）日：2014-09-25

  The present invention provides compositions and methods for providing controllable local delivery of a therapeutic agent to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with osteoporosis, bone cancer or bone fracture. The invention provides a therapeutic agent that is tethered to a polymer to form a therapeutic-tethered macromer, where the therapeutic agent is controllably released from the conjugate by degradation of the tether. In certain embodiments, the therapeutic agent is an inhibitor of GSK3β. In certain embodiments, the composition of the invention is specifically targeted to a site in need of bone formation.