US10112937, Example 395

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: US10112937, Example 395
• 英文别名: (2,3-dichlorophenyl)-[(4S)-4-methyl-1-(4-methylpyridin-2-yl)-6,7-dihydro-4H-triazolo[4,5-c]pyridin-5-yl]methanone
• 化学式: C₁₉H₁₇Cl₂N₅O
• 分子量: 402.3
• InChiKey: YMZRPAMOYRNYTO-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  63.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• P2X7 MODULATORS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20160039809A1

  公开（公告）日：2016-02-11

  The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb). The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.

  本发明涉及化合物I、Ia、IIa和IIb的公式。本发明还涉及包含化合物I、Ia、IIa和IIb的制药组合物。制备和使用化合物I、Ia、IIa和IIb的方法也在本发明的范围内。
• P2X7 modulators and methods of use
  申请人：Janssen Pharmaceutica NV

  公开号：US10112937B2

  公开（公告）日：2018-10-30

  The present invention is directed to compounds of Formulas (I, Ia, IIa and IIb). The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, Ia, IIa and IIb). Methods of making and using the compounds of Formulas (I, Ia, IIa and IIb) are also within the scope of the invention.

  本发明涉及式（I、Ia、IIa 和 IIb）化合物。本发明还涉及包含式（I、Ia、IIa 和 IIb）化合物的药物组合物。式（I、Ia、IIa 和 IIb）化合物的制造和使用方法也属于本发明的范围。
• [EN] P2X7 MODULATORS<br/>[FR] MODULATEURS DU RÉCEPTEUR P2X7
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014152604A1

  公开（公告）日：2014-09-25

  The present invention is directed to compounds of Formulas (I, la, lla and IIb). The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, la, lla and IIb). Methods of making and using the compounds of Formulas (I, la, lla and IIb) are also within the scope of the invention.