(2,4-Difluoro-3-phenylmethoxyphenyl) 2-methylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: (2,4-Difluoro-3-phenylmethoxyphenyl) 2-methylpropanoate
• 英文别名: (2,4-difluoro-3-phenylmethoxyphenyl) 2-methylpropanoate
• 化学式: C₁₇H₁₆F₂O₃
• 分子量: 306.3
• InChiKey: MLBDAWXSMXPPJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120<br/>[FR] DÉRIVÉS BICYCLIQUES DE PYRROLE, UTILES COMME AGONISTES DE GPR120
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2015134038A1

  公开（公告）日：2015-09-11

  The present invention is directed to bicyclic pyrrole derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example. Type II diabetes mellitus.

  本发明涉及式(I)的双环吡咯衍生物、含有它们的药物组合物及其在治疗由GPR120调节的疾病和状况中的用途。更具体地说，本发明的化合物是GPR120的激动剂，可用于治疗诸如2型糖尿病等疾病。
• BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2970182A1

  公开（公告）日：2016-01-20
• [EN] BICYCLIC PYRROLE DERIVATIVES USEFUL AS AGONISTS OF GPR120<br/>[FR] DÉRIVÉS PYRROLES BICYCLIQUES UTILES EN TANT QU'AGONISTES DE GPR120
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014149987A1

  公开（公告）日：2014-09-25

  The present invention is directed to bicyclic pyrrole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus.