4'-(aminomethyl)-N-{4-methoxy-3-[(morpholin-4-ylacetyl)amino]phenyl}biphenyl-4-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-(aminomethyl)-N-{4-methoxy-3-[(morpholin-4-ylacetyl)amino]phenyl}biphenyl-4-carboxamide
• 英文别名: 4-[4-(aminomethyl)phenyl]-N-[4-methoxy-3-[(2-morpholin-4-ylacetyl)amino]phenyl]benzamide
• 化学式: C₂₇H₃₀N₄O₄
• 分子量: 474.56
• InChiKey: SOLLLHZXTLCNSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  tert-butyl {[4'-({4-methoxy-3-[(morpholin-4-ylacetyl)amino]phenyl}carbamoyl)biphenyl-4-yl]methyl}-carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以34%的产率得到4'-(aminomethyl)-N-{4-methoxy-3-[(morpholin-4-ylacetyl)amino]phenyl}biphenyl-4-carboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
  [FR] NOUVEAUX COMPOSÉS

  摘要：

  公开号：

  WO2014147182A3

文献信息

• NOVEL COMPOUNDS
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20160052898A1

  公开（公告）日：2016-02-25

  The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式(I)所述的替代N-联苯基-3-乙酰氨基苯甲酰胺和N-[3-(乙酰氨基)苯基]-联苯基甲酰胺，以及制备该化合物的方法，用于制备该化合物的中间体化合物，包含该化合物的制药组合物和药物组合，以及利用该化合物制备治疗或预防疾病的药物组合，特别是治疗增生性疾病的药物组合，作为唯一的药物或与其他活性成分组合使用。
• SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2976343A2

  公开（公告）日：2016-01-27
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：BAYER PHARMA AG

  公开号：WO2014147182A2

  公开（公告）日：2014-09-25

  The present invention relates substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
• [EN] SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：BAYER PHARMA AG

  公开号：WO2014147182A3

  公开（公告）日：2014-11-13