N-[[3-[[6-(4-aminophenyl)pyridin-3-yl]-(2-morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)phenyl]-[[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]-[3-[(2-morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)benzoyl]amino]methyl]-N-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-[(2-morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[3-[[6-(4-aminophenyl)pyridin-3-yl]-(2-morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)phenyl]-[[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]-[3-[(2-morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)benzoyl]amino]methyl]-N-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]-3-[(2-morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)benzamide
• 化学式: C₆₉H₅₉F₁₁N₁₄O₁₁S₂
• 分子量: 1533.4
• InChiKey: PWRBFWKMEYOKMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  107
• 可旋转键数：
  23
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  331
• 氢给体数：
  3
• 氢受体数：
  33

文献信息

• 3-ACETYLAMINO-1-(PHENYL-HETEROARYL-AMINOCARBONYL OR PHENYL-HETEROARYL-CARBONYLAMINO)BENZENE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2976327A2

  公开（公告）日：2016-01-27
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：BAYER PHARMA AG

  公开号：WO2014147021A2

  公开（公告）日：2014-09-25

  The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N- [3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula(I) as described and defined herein,to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.