N-[1-(biphenyl-4-yl)-1-(4-trifluoromethylphenyl)methyl]-P,P-diphenylphosphinamide | 1190207-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[1-(biphenyl-4-yl)-1-(4-trifluoromethylphenyl)methyl]-P,P-diphenylphosphinamide
• 英文别名: (1R)-N-diphenylphosphoryl-1-(4-phenylphenyl)-1-[4-(trifluoromethyl)phenyl]methanamine
• CAS: 1190207-42-1
• 化学式: C₃₂H₂₅F₃NOP
• 分子量: 527.526
• InChiKey: SHOTYVCTVRKBMD-WJOKGBTCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  P,P-diphenyl-N-(4-(trifluoromethyl)benzylidene)phosphinic amide 、 2,4,6-tris([1,1'-biphenyl]-4-yl)boroxine 在 acetylacetonatobis(ethylene)rhodium(I) 、 tert-butyl N-{1-(R)-[(2-(S)-bis(2-methylphenyl)phosphinomethyl)pyrrolidine-1-carbonyl]-2-methylpropyl}-carbamate 作用下， 以 1,4-二氧六环 、 丙醇 为溶剂， 反应 12.0h， 以83%的产率得到N-[1-(biphenyl-4-yl)-1-(4-trifluoromethylphenyl)methyl]-P,P-diphenylphosphinamide
  参考文献：
  名称：

  Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to N-Phosphinoyl Aldimines

  摘要：

  Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-phosphinoylaldi mines was realized by the steric tuning of a cliphenylphosphorus moiety to a di(o-tolyl) phosphorus moiety of a chiral amidomonophosphane. The presence of MS 4 A in a 5:1 solvent mixture of dioxane-propanol was essential to afford the corresponding diarylmethylamines in high yield.

  DOI：

  10.1021/ol901866y

文献信息

• Steric Tuning of the Amidomonophosphane-Rhodium(I) Catalyst in Asymmetric Addition of Arylboroxines to <i>N</i>-Phosphinoyl Aldimines
  作者：Xinyu Hao、Masami Kuriyama、Qian Chen、Yasutomo Yamamoto、Ken-ichi Yamada、Kiyoshi Tomioka

  DOI：10.1021/ol901866y

  日期：2009.10.1

  Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-phosphinoylaldi mines was realized by the steric tuning of a cliphenylphosphorus moiety to a di(o-tolyl) phosphorus moiety of a chiral amidomonophosphane. The presence of MS 4 A in a 5:1 solvent mixture of dioxane-propanol was essential to afford the corresponding diarylmethylamines in high yield.