methyl 2-methoxy-4-(3-morpholinoisothiazolo[4,3-b]pyridin-6-yl)benzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 2-methoxy-4-(3-morpholinoisothiazolo[4,3-b]pyridin-6-yl)benzoate
• 英文别名: Methyl 2-methoxy-4-(3-morpholinoisothiazolo[4,3-b]pyridin-6-yl)benzoate；methyl 2-methoxy-4-(3-morpholin-4-yl-[1,2]thiazolo[4,3-b]pyridin-6-yl)benzoate
• 化学式: C₁₉H₁₉N₃O₄S
• 分子量: 385.444
• InChiKey: SBYPSCKVVSCJHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  6-bromo-3-morpholinoisothiazolo[4,3-b]pyridine 、 3-甲氧基-4-甲氧羰基苯硼酸 、 potassium carbonate 在 四(三苯基膦)钯 cyclohexane, ethyl acetate 作用下， 以affording the title compound in 66% yield (51 mg, 0.132 mmol)的产率得到methyl 2-methoxy-4-(3-morpholinoisothiazolo[4,3-b]pyridin-6-yl)benzoate
  参考文献：
  名称：

  NOVEL GAK MODULATORS

  摘要：

  本发明涉及一类新型异噻唑并[4,3-b]吡啶衍生物及其制备方法，以及包含一种或多种所述异噻唑并[4,3-b]吡啶衍生物和一种或多种药学上可接受的辅料的制药组合物。本发明还涉及使用所述新型异噻唑并[4,3-b]吡啶衍生物作为生物活性成分，更具体地作为治疗细胞增殖和神经退行性疾病等疾病和病理情况的药物。

  公开号：

  US20160122364A1

文献信息

• [EN] NOVEL GAK MODULATORS<br/>[FR] NOUVEAUX MODULATEURS DE LA GAK
  申请人：UNIV LEUVEN KATH

  公开号：WO2015001076A1

  公开（公告）日：2015-01-08

  The present invention relates to a class of novel isothiazolo[4,3-b]pyridine derivatives and a method for their preparation, as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3-b]pyridine derivatives and one or more pharmaceutically acceptable excipients. The present invention further relates to the use of said novel isothiazolo[4,3-b]pyridine derivatives as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, cell-proliferative and neurodegenerative diseases.

  本发明涉及一类新型的异噻唑并[4,3-b]吡啶衍生物及其制备方法，以及包含一种或多种所述异噻唑并[4,3-b]吡啶衍生物和一种或多种药学上可接受的赋形剂的药物组合物。本发明还涉及所述新型异噻唑并[4,3-b]吡啶衍生物作为生物活性成分的用途，更具体地，作为用于治疗诸如但不限于细胞增殖性和神经退行性疾病等障碍和病理状况的药物。
• [EN] GAK MODULATORS AS ANTIVIRALS<br/>[FR] MODULATEURS DE GAK A TITRE D'AGENTS ANTIVIRAUX
  申请人：UNIV LEUVEN KATH

  公开号：WO2016012536A1

  公开（公告）日：2016-01-28

  The present invention relates to the use of a class of novel isothiazolo[4,3-b]pyridine derivatives as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3- b]pyridine derivatives and one or more pharmaceutically acceptable excipients as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as viral diseases.

  本发明涉及一类新型异噻唑并[4,3-b]吡啶衍生物的使用，以及包含一种或多种所述异噻唑并[4,3-b]吡啶衍生物和一种或多种药学上可接受的赋形剂作为生物活性成分的药物组合物，更具体地，作为用于治疗诸如病毒性疾病等疾病和病理状况的药物。
• GAK MODULATORS AS ANTIVIRALS
  申请人：Katholieke Universiteit Leuven

  公开号：US20170152271A1

  公开（公告）日：2017-06-01

  The present invention relates to the use of a class of novel isothiazolo[4,3-b]pyridine derivatives as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3-b]pyridine derivatives and one or more pharmaceutically acceptable excipients as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as viral diseases.
• US9518066B2
  申请人：——

  公开号：US9518066B2

  公开（公告）日：2016-12-13
• US9822127B2
  申请人：——

  公开号：US9822127B2

  公开（公告）日：2017-11-21