ethyl 2-(6-methoxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)acetate | 1222172-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: ethyl 2-(6-methoxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)acetate
• 英文别名: Ethyl 2-(6-methoxy-4-oxo-2,3-dihydrochromen-2-yl)acetate；ethyl 2-(6-methoxy-4-oxo-2,3-dihydrochromen-2-yl)acetate
• CAS: 1222172-61-3
• 化学式: C₁₄H₁₆O₅
• 分子量: 264.278
• InChiKey: VUEALYOEIVXNMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2'-羟基-5'-甲氧基苯乙酮 、 丙炔酸乙酯 在 三乙烯二胺 、 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以72%的产率得到ethyl 2-(6-methoxy-4-oxo-3,4-dihydro-2H-chromen-2-yl)acetate
  参考文献：
  名称：

  One-pot reaction of ortho-acylphenols and terminal alkynoates for synthesis of 2-alkyl-substituted chromanones

  摘要：

  A facile synthesis of 2-alkyl-substituted chromanones from ortho-acylphenols and terminal alkynoates is described. The method contains two consecutive processes in one-pot reaction through a DABCO-catalyzed condensation reaction and a KOBu'-mediated intramolecular cycloaddition to afford the desired products. (C) 2010 Elsevier Ltd. All Fights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.093

文献信息

• One-pot reaction of ortho-acylphenols and terminal alkynoates for synthesis of 2-alkyl-substituted chromanones
  作者：Ling-Guo Meng、Hui-Fang Liu、Jian-Long Wei、Sun-Na Gong、Song Xue

  DOI：10.1016/j.tetlet.2010.01.093

  日期：2010.3

  A facile synthesis of 2-alkyl-substituted chromanones from ortho-acylphenols and terminal alkynoates is described. The method contains two consecutive processes in one-pot reaction through a DABCO-catalyzed condensation reaction and a KOBu'-mediated intramolecular cycloaddition to afford the desired products. (C) 2010 Elsevier Ltd. All Fights reserved.