2,3,7,8-dibenzo-5-diethylaminomethyl-1,6-dioxa-4,9-diaza-5-phosphaspiro<4,4>nonane | 135626-07-2

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 2,3,7,8-dibenzo-5-diethylaminomethyl-1,6-dioxa-4,9-diaza-5-phosphaspiro<4,4>nonane
• 英文别名: 2-diethylaminomethyl-2,2'-spirobi(1,3,2-benzoxazaphospholine)；2-<(diethylamino)methyl>-2,2'-spirobi(1,3,2-benzoxaphospholine)；2-diethylaminomethyl-2,2'-spirodi[benzo-1,3,2-oxazaphospholine]；2-diethylaminomethyl-2,2-spirobis(1,3,2-benzoxaphospholine)；N-ethyl-N-(2,2'-spirobi[3H-1,3,2lambda5-benzoxazaphosphole]-2-ylmethyl)ethanamine；N-ethyl-N-(2,2'-spirobi[3H-1,3,2λ5-benzoxazaphosphole]-2-ylmethyl)ethanamine
• CAS: 135626-07-2
• 化学式: C₁₇H₂₂N₃O₂P
• 分子量: 331.354
• InChiKey: WEMRWGCZBUAVRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-diethylamino-3-diethylaminomethyl-1,3,2-benzoxazaphospholine 在 乙醇 作用下， 以 乙醚 为溶剂， 反应 24.0h， 以35%的产率得到2,3,7,8-dibenzo-5-diethylaminomethyl-1,6-dioxa-4,9-diaza-5-phosphaspiro<4,4>nonane
  参考文献：
  名称：

  Pudovik, M. A.; Terent'eva, S. A.; Pudovik, A. N., Journal of general chemistry of the USSR, 1992, vol. 62, # 2.1, p. 224 - 228

  摘要：

  DOI：

文献信息

• ——
  作者：S. A. Terent'eva、M. A. Pudovik、A. T. Gubaidullin、I. A. Litvinov、A. N. Pudovik

  DOI：10.1023/a:1012392614866

  日期：——

  Chloromethylphosphonic dichloride reacts with o-aminophenol in the presence of triethylamine to form 2-chloromethyl-1,3,2-benzoxazaphospholine 2-oxide and 2-chloromethyl-2,2'-spirodi[1,3,2-benzoxazaphospholine] in a 1 : 1 ratio. 3-Diethylaminomethyl-2-ethoxy-1,3,2-benzoxazaphospholine reacts with o-aminophenol to form 2-diethylaminomethyl-2,2'-spirodi[benzo-1,3,2-oxazaphospholine]. The crystal and molecular structures of the synthesized spirophosphoranes were determined by single crystal X-ray diffraction.
• Reaction of 2-diethylamino-3-diethylaminomethyl-1,3,2-benzoxazaphospholine with hydroxyl-containing compounds
  作者：M. A. Pudovik、S. A. Terent'eva、I. A. Litvinov、O. N. Kataeva、V. A. Naumov、A. N. Pudovik

  DOI：10.1007/bf00697046

  日期：1993.10

  The reaction of 2-diethylamino-3-diethylaminomethyl-1,3,2-benzoxazaphospholine with functionally substituted alcohols and phenols occurs with the cleavage of exocyclic P-N bond followed by N-->P migration of the diethylaminomethyl group and formation of imidophosphonate dimers. A similar reaction with polyhydroxy compounds (diethylene glycol, glycerol) results in symmetrical and asymmetrical spirophosphoranes.
• Pudovik, M. A.; Terent'eva, S. A.; Pudovik, A. N., Journal of general chemistry of the USSR, 1991, vol. 61, # 3.2, p. 698
  作者：Pudovik, M. A.、Terent'eva, S. A.、Pudovik, A. N.

  DOI：——

  日期：——
• PUDOVIK, M. A.;TERENTEVA, S. A.;PUDOVIK, A. N., ZH. OBSHCH. XIMII, 61,(1991) N, S. 770-771
  作者：PUDOVIK, M. A.、TERENTEVA, S. A.、PUDOVIK, A. N.

  DOI：——

  日期：——