3-Pyridinecarboxylic acid, 6-(3,3-diphenylpropyl)-1,2,5,6-tetrahydro- | 653576-62-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Pyridinecarboxylic acid, 6-(3,3-diphenylpropyl)-1,2,5,6-tetrahydro-
• 英文别名: 2-(3,3-diphenylpropyl)-1,2,3,6-tetrahydropyridine-5-carboxylic acid
• CAS: 653576-62-6
• 化学式: C₂₁H₂₃NO₂
• 分子量: 321.4
• InChiKey: GTZKFZYHYBKSGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• (R) ENANATIOMER OF APLEXONE
  申请人：The Regents of the University of California

  公开号：US20220009891A1

  公开（公告）日：2022-01-13

  R-aplexone, methods of preparing R-aplexone, or aplexone substantially free of its S-stereoisomer are disclosed. Methods of using R-aplexone or a pharmaceutically acceptable salt or solvate thereof to treat and/or prevent disease are disclosed. Methods of preparing 6-substituted tetrahydropyridine motifs with high enantiomeric excess are also disclosed.

  本文披露了制备R-aplexone、制备基本不含其S-立体异构体的aplexone的方法。本文还披露了使用R-aplexone或其药学上可接受的盐或溶剂来治疗和/或预防疾病的方法。本文还披露了制备具有高对映体过量的6-取代四氢吡啶基团的方法。
• [EN] (R) ENANTIOMER OF APLEXONE<br/>[FR] ÉNANTIOMÈRE (R) D'APLEXONE
  申请人：UNIV CALIFORNIA

  公开号：WO2020061247A1

  公开（公告）日：2020-03-26

  R-aplexone, methods of preparing R- aplexone, or aplexone substantially free of its S- stereoisomer are disclosed. Methods of using R-aplexone or a pharmaceutically acceptable salt or solvate thereof to treat and/or prevent disease are disclosed. Methods of preparing 6- substituted tetrahydropyridine motifs with high enantiomeric excess are also disclosed.