(3aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-(3ar,7ac)-octahydro-indol-6-one; hydrochloride | 64643-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3aS)-3a-(3,4-dimethoxy-phenyl)-1-methyl-(3ar,7ac)-octahydro-indol-6-one; hydrochloride
• 英文别名: (3aS)-3a-(3,4-Dimethoxy-phenyl)-1-methyl-(3ar,7ac)-octahydro-indol-6-on; Hydrochlorid；(3aS,7aS)-3a-(3,4-dimethoxyphenyl)-1-methyl-2,3,4,5,7,7a-hexahydroindol-6-one;hydrochloride
• CAS: 64643-83-0
• 化学式: C₁₇H₂₃NO₃*ClH
• 分子量: 325.835
• InChiKey: AWTUIVVWCZGIAQ-QJHJCNPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  38.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SCELETIUM EXTRACT AND USES THEREOF
  申请人：HG&H Pharmaceuticals (Pty) Limited

  公开号：EP2408460B1

  公开（公告）日：2018-09-26
• USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING MESEMBRENONE
  申请人：H.l. Hall & Sons Limited

  公开号：EP2408446A1

  公开（公告）日：2012-01-25
• NOVEL COMPOSITION FOR THE TREATMENT OF CYSTIC FIBROSIS
  申请人：SciPharm SàRL

  公开号：EP2672957B1

  公开（公告）日：2016-11-02
• Sceletium Extract and Uses Thereof
  申请人：H. L. Hall & Sons Limited

  公开号：US20150080447A1

  公开（公告）日：2015-03-19

  A composition including as an active ingredient an extract of a plant of the family Mesembryanthemaceae with mesembrenol and mesembrenone as the two major alkaloids present. The invention also relates to the use of the composition as a PDE4 inhibitor and as a serotonin-uptake inhibitor, preferably applied in formulations for the use of the composition as a dual serotonin-uptake inhibitor and PDE4 inhibitor. The invention extends to compositions, such as pharmaceutical compositions or compositions used as dietary supplements, the total alkaloid content of which includes at least 80% (w/w) combined content of mesembrenol and mesembrenone, less than 5% (w/w) mesembrine, and at least 7% (w/w) mesembranol.
• US8552051B2
  申请人：——

  公开号：US8552051B2

  公开（公告）日：2013-10-08