(2-Chloro-phenyl)-[3-(5-methyl-furan-2-yl)-propyl]-amine | 154264-97-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-Chloro-phenyl)-[3-(5-methyl-furan-2-yl)-propyl]-amine
• 英文别名: 2-chloro-N-[3-(5-methylfuran-2-yl)propyl]aniline
• CAS: 154264-97-8
• 化学式: C₁₄H₁₆ClNO
• 分子量: 249.74
• InChiKey: JIVLCRZKHWCOHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-Chloro-phenyl)-[3-(5-methyl-furan-2-yl)-propyl]-amine 在 吡啶 、 lithium aluminium tetrahydride 作用下， 生成 (2-Chloro-phenyl)-bis-[3-(5-methyl-furan-2-yl)-propyl]-amine
  参考文献：
  名称：

  Intramolecular Diels-Alder Reaction of Benzynes: A Novel Strategy for the Construction of Tetrahydrobenzazepine Skeletons

  摘要：

  Intramolecular Diels-Alder reaction of benzynes, generated from ortho-haloaniline derivatives by the action of lithium 2,2,6,6-tetramethylpiperidide, with furans has been developed as a novel route for the construction of tetrahydrobenzazepine skeletons.

  DOI：

  10.3987/com-93-6557
• 作为产物：
  描述：

  3-<5-Methyl-<2>furyl>-propionylchlorid 在 吡啶 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (2-Chloro-phenyl)-[3-(5-methyl-furan-2-yl)-propyl]-amine
  参考文献：
  名称：

  Intramolecular Diels-Alder Reaction of Benzynes: A Novel Strategy for the Construction of Tetrahydrobenzazepine Skeletons

  摘要：

  Intramolecular Diels-Alder reaction of benzynes, generated from ortho-haloaniline derivatives by the action of lithium 2,2,6,6-tetramethylpiperidide, with furans has been developed as a novel route for the construction of tetrahydrobenzazepine skeletons.

  DOI：

  10.3987/com-93-6557

文献信息

• Intramolecular Diels-Alder Reaction of Benzynes: A Novel Strategy for the Construction of Tetrahydrobenzazepine Skeletons
  作者：Hiyoshizo Kotsuki、Tadahiro Nobori、Toshihiro Asada、Masamitsu Ochi

  DOI：10.3987/com-93-6557

  日期：——

  Intramolecular Diels-Alder reaction of benzynes, generated from ortho-haloaniline derivatives by the action of lithium 2,2,6,6-tetramethylpiperidide, with furans has been developed as a novel route for the construction of tetrahydrobenzazepine skeletons.