(E)-4-hydroxy-3-phenylbut-3-en-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-4-hydroxy-3-phenylbut-3-en-2-one
• 化学式: C₁₀H₁₀O₂
• 分子量: 162.18
• InChiKey: IEKCKXIUVQTQTF-YFHOEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Alpha-7 Nicotinic Acetylcholine Receptor Allosteric Modulators, Their Derivatives and Uses Thereof
  申请人：Anvyl LLC

  公开号：US20140194462A1

  公开（公告）日：2014-07-10

  The present application is related to compounds represented by Formula I, which are novel allosteric modulators of α7nAChR. The application also discloses the treatment of disorders that are responsive to modulation of acetylcholine action on α7nAChR in a mammal by administering an effective amount of a compound of Formula I.

  本申请涉及由公式I表示的化合物，它们是α7nAChR的新型变构调节剂。该申请还披露了通过给哺乳动物投与公式I化合物的有效量来调节乙酰胆碱对α7nAChR的作用，从而治疗对调节乙酰胆碱作用敏感的疾病。
• 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0061774A2

  公开（公告）日：1982-10-06

  1-R1-3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridi- nones or salts thereof, which are useful as cardiotonics, where R, is hydrogen, lower-alkyl, or lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and, R' and R" are each hydrogen, hydroxy or amino at least one of R' or R" being other than hydrogen, are prepared by reacting the corresponding 3-carbamyl compound with a reagent capable of converting carbamyl to amino or by first reacting the corresponding 3-carbamyl compound where R' and R" are each hydrogen, nitro or lower-alkoxy with a reagent capable of converting carbamyl to amino and then reacting the resulting 3-amino compound where R' and/or R" are/is lower-alkoxy and/or nitro with a reagent capable of converting lower-alkoxy to hydroxy and/or with a reagent capable of converting nitro to amino. Preparation of the corresponding 3-carbamyl and 3-cyano compounds are described. The invention also concerns the 3- and/or 4-methoxy intermediates and certain novel 3-cyano analogs. Cyano compounds are also useful as cardiotonics.

  1-R1-3-氨基-5-(3-R'-4-R"-苯基)-6-R-2(1H)-吡啶-壬烷或其盐，可用作强心剂，其中 R 是氢、低级烷基或低级羟基烷基，R 是氢或低级烷基，R'和 R "各自是氢、羟基或氨基，R'或 R "中至少有一个不是氢、将相应的 3-氨基甲酰基化合物与能将氨基甲酰基转化为氨基的试剂反应，或先将 R' 和 R "均为氢、硝基或低级烷氧基的相应 3-氨基甲酰基化合物与能将氨基甲酰基转化为氨基的试剂反应，然后将所得 R' 和/或 R "为/或低级烷氧基和/或硝基的 3-氨基化合物与能将低级烷氧基转化为羟基的试剂和/或能将硝基转化为氨基的试剂反应，制备 3-氨基甲酰基化合物。本发明描述了相应的 3-氨基甲酰基和 3-氰基化合物的制备方法。本发明还涉及 3-和/或 4-甲氧基中间体和某些新型 3-氰基类似物。氰基化合物还可用作强心剂。
• 2(1H)-pyridinones and preparation thereof
  申请人：STERLING DRUG INC.

  公开号：EP0074091A2

  公开（公告）日：1983-03-16

  Novel 1-R,-3-Q-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinones where R, is hydrogen, lower-alkyl or lower-hydroxyalkyl, R is lower-alkyl and, R' and R" are each hydrogen, amino or hydroxy, at least one of R' or R" being other than hydrogen, or R is nitro and R" is hydroxy, are useful as cardiotonics. Also known compounds where R is hydrogen are useful as cardiotonics. Both novel and known compounds can be prepared by a novel process which comprises reacting 1-RI-1,2-dihydro-2-oxo-5-(3-R'-4-R"- phenyl)-6-R-nicotinonitrile, where R1 and R are defined as above, R' is hydrogen, hydroxy, methoxy or amino and R" is hydrogen, hydroxy, amino or methoxy, at least one of R' and R" being other than hydrogen, or R' is nitro and R" is hydroxy with 85% phosphoric acid.

  新型 1-R,-3-Q-5-(3-R'-4-R"-苯基)-6-R-2(1H)-吡啶酮，其中 R 是氢、低级烷基或低级羟基烷基，R 是低级烷基，R'和 R "各自是氢、氨基或羟基，R'或 R "中至少有一个不是氢，或 R 是硝基，R "是羟基，可用作强心剂。此外，R 为氢的已知化合物也可用作强心剂。新型和已知化合物均可通过一种新型工艺制备，该工艺包括将 1-RI-1,2-二氢-2-氧代-5-(3-R'-4-R"-苯基)-6-R-烟腈（其中 R1 和 R 定义如上，R'为氢、羟基、甲氧基或氨基，R "为氢、羟基、氨基或甲氧基，R'和 R "中至少有一个不是氢，或 R'为硝基，R "为羟基）与 85%的磷酸反应。
• US3957817A
  申请人：——

  公开号：US3957817A

  公开（公告）日：1976-05-18
• US4100185A
  申请人：——

  公开号：US4100185A

  公开（公告）日：1978-07-11