N-[4-(2-Cyclopropylamino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(2-Cyclopropylamino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide
• 英文别名: N-[4-[2-(cyclopropylamino)-1-hydroxyethyl]phenyl]methanesulfonamide
• 化学式: C₁₂H₁₈N₂O₃S
• 分子量: 270.353
• InChiKey: YCLARTFQOFFTBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Ultra short acting anti-arrhythmic agents
  申请人：Academic Pharmaceuticals Incorporated

  公开号：US11286235B2

  公开（公告）日：2022-03-29

  The present invention provides novel sotalol derivatives and pharmaceutical compositions containing the same that are are useful as pharmaceutical agents in the treatment of supraventricular and ventricular arrhythmias.

  本发明提供了新型索他洛尔衍生物和含有这种衍生物的药物组合物，它们可用作治疗室上性和室性心律失常的药物。
• ULTRA SHORT ACTING ANTI-ARRHYTHMIC AGENTS
  申请人：Academic Pharmaceuticals Incorporated

  公开号：US20210107867A1

  公开（公告）日：2021-04-15

  The present invention provides novel sotalol derivatives and pharmaceutical compositions containing the same that are are useful as pharmaceutical agents in the treatment of supraventricular and ventricular arrhythmias.