4-Vinyl-N-cetylpyridinium | 48203-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Vinyl-N-cetylpyridinium
• 英文别名: 4-ethenyl-1-hexadecylpyridin-1-ium;bromide
• CAS: 48203-86-7
• 化学式: C23H40BrN
• 分子量: 410.5
• InChiKey: SHKJPLSMOIRNPI-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Compositions and methods for inducing activation of dendritic cells
  申请人：——

  公开号：US20030118550A1

  公开（公告）日：2003-06-26

  Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.

  诱导树突状细胞活化的组合物由多核苷酸（如病毒、RNA、DNA、质粒 DNA 或其衍生物）和至少一种烷基醚嵌段共聚物组成。本发明还涉及用于诱导树突状细胞活化的组合物，其中嵌段共聚物为 PLURONIC F127 和 L61。更具体地说，组合物包括嵌段共聚物PLURONIC F127/PLURONIC L61。本发明还涉及诱导动物树突状细胞活化的方法，包括施用本发明的组合物。此外，本发明还涉及增加动物免疫反应的方法，包括施用本发明的组合物。
• Polynucleotide compositions
  申请人：——

  公开号：US20030198678A1

  公开（公告）日：2003-10-23

  Compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. In one aspect, the invention provides a polynucleotide complex between a polynucleotide and certain polyether block copolymers. The polynucleotide complex can further include a polycationic polymer, as well as suitable targeting molecules and surfactants. The invention also provides a polynucleotide complex between a polynucleotide and a block copolymer comprising a polyether block and a polycation block.

  用于稳定多核酸和提高多核酸穿过细胞膜并在细胞内部发挥作用的能力的复合物。一方面，本发明提供了一种多核苷酸与某些聚醚嵌段共聚物之间的多核苷酸复合物。多核苷酸复合物可进一步包括多阳离子聚合物以及合适的靶向分子和表面活性剂。本发明还提供了一种多核苷酸与由聚醚嵌段和聚阳离子嵌段组成的嵌段共聚物之间的多核苷酸复合物。
• POLYNUCLEOTIDE COMPOSITIONS
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP0789564A1

  公开（公告）日：1997-08-20
• EP0789564A4
  申请人：——

  公开号：EP0789564A4

  公开（公告）日：2000-11-08
• EP1140015A4
  申请人：——

  公开号：EP1140015A4

  公开（公告）日：2003-08-06