2-amino-5-hydroxy-4-methylbenzoic acid | 909391-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-5-hydroxy-4-methylbenzoic acid
• CAS: 909391-41-9
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: YZUKNPZJZZSSEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-Amino-5-methoxy-4-methyl-benzoesaeure 在 乙醚 作用下， 以 氢碘酸 为溶剂， 反应 36.0h， 以to yield 2-amino-5-hydroxy-4-methylbenzoic acid (INTERMEDIATE V.1) (2.5 g, 14.9 mmol 100%)的产率得到2-amino-5-hydroxy-4-methylbenzoic acid
  参考文献：
  名称：

  2-(4-oxo-4H-quinazolin-3-yl)acetamides and their use as vasopressin V3 antagonists

  摘要：

  本发明涉及式(I)的2-(4-氧代-4H-喹唑啉-3-基)乙酰胺类衍生物，以及它们作为抗利尿激素V3拮抗剂的用途，特别是用于治疗抑郁症。

  公开号：

  US07807686B2

文献信息

• 2-(4-Oxo-4H-Quinazolin-3-Yl) Acetamides and Their Use as Vasopressin V3 Antagonists
  申请人：Letourneau Jeffrey

  公开号：US20080214553A1

  公开（公告）日：2008-09-04

  The present invention relates to 2-(4-oxo4H-quinazolin-3-yl)acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression.

  本发明涉及公式（I）的2-（4-氧代4H-喹唑啉-3-基）乙酰胺衍生物，以及它们作为利尿激素V3拮抗剂的用途，特别是用于治疗抑郁症。
• Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
  申请人：HIMMELSBACH Frank

  公开号：US20100267718A1

  公开（公告）日：2010-10-21

  The present invention relates to bicyclic heterocycles of general formula wherein R a , R b , R c , R d , X and n are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibiting effect on the signal transduction mediated by tyrosine kinases, their use in treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract and the preparation thereof.

  本发明涉及一般式为的双环杂环化合物，其中Ra、Rb、Rc、Rd、X和n如权利要求1所定义，它们的互变异构体、立体异构体、混合物及其盐，特别是它们与无机或有机酸形成的生理上可接受的盐具有有价值的药理学特性，特别是对由酪氨酸激酶介导的信号传导具有抑制作用，它们的用途在于治疗疾病，特别是肿瘤性疾病、良性前列腺增生症（BPH）、肺和呼吸道疾病以及其制备方法。
• WO2006/95014
  申请人：——

  公开号：——

  公开（公告）日：——
• 2-(4-OXO-4H-QUINAZOLIN-3-YL)ACETAMIDES AND THEIR USE AS VASOPRESSIN V3 ANTAGONISTS
  申请人：N.V. Organon

  公开号：EP1861380A1

  公开（公告）日：2007-12-05
• PROCESS FOR DYEING IN THE PRESENCE OF OXIDATION BASES COMPRISING AT LEAST ONE SULFONIC, SULFONAMIDE, SULFONE, AMID OR ACID GROUP AND A METAL CATALYST, DEVICE AND READY-TO-USE COMPOSITION
  申请人：L'OREAL

  公开号：US20160143826A1

  公开（公告）日：2016-05-26

  The present invention relates to a process for dyeing human keratin fibres, in which use is made of one or more metal catalysts and a composition (A) comprising: (a) at least 10% by weight of one or more fatty substances, (b) one or more oxidation bases of formula (I) or (II), the addition salts thereof, solvates thereof and mixtures thereof: Formula (I), Formula (II) (c) one or more chemical oxidizing agents other than atmospheric oxygen. The invention also relates to a multi-compartment device and to a composition comprising all of the above-mentioned ingredients.