2-Chloro-5-[(4E)-3-methyl-5-oxo-4-{[3-(thiophene-2-carbonyloxy)phenyl]methylidene}-4,5-dihydro-1H-pyrazol-1-YL]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-5-[(4E)-3-methyl-5-oxo-4-{[3-(thiophene-2-carbonyloxy)phenyl]methylidene}-4,5-dihydro-1H-pyrazol-1-YL]benzoic acid
• 英文别名: 2-chloro-5-[(4E)-3-methyl-5-oxo-4-[[3-(thiophene-2-carbonyloxy)phenyl]methylidene]pyrazol-1-yl]benzoic acid
• 化学式: C₂₃H₁₅ClN₂O₅S
• 分子量: 466.9
• InChiKey: HPKQVMDTCNUSQC-GZTJUZNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR
  申请人：RYDER Sean

  公开号：US20110065704A1

  公开（公告）日：2011-03-17

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
• US8377639B2
  申请人：——

  公开号：US8377639B2

  公开（公告）日：2013-02-19
• US8962244B2
  申请人：——

  公开号：US8962244B2

  公开（公告）日：2015-02-24
• [EN] COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR<br/>[FR] COMPOSÉS DE MODULATION DES PROTÉINES DE LIAISON À L'ARN ET APPLICATIONS ASSOCIÉES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2010151797A2

  公开（公告）日：2010-12-29

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.