Fmoc-Val-CHO | 810682-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Val-CHO
• 英文别名: 9H-fluoren-9-ylmethyl N-[(3S)-4-methyl-1,2-dioxopentan-3-yl]carbamate
• CAS: 810682-74-7
• 化学式: C₂₁H₂₁NO₄
• 分子量: 351.402
• InChiKey: IBNNMDOOOXCDFX-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Fmoc-Ala-CHO 、 Fmoc-Val-CHO 、 Fmoc-Pro-CHO 生成 H-Ala-Ala-Pro-Val-ψ[CO-CH=N]-Ala-Ala-OH
  参考文献：
  名称：

  Efficient and direct solid phase synthesis of ketomethylenimino and ketomethylenamino peptides

  摘要：

  The aim of this study is the synthesis of pseudopeptides on solid supports, in order to quickly obtain modified peptides. We report a convenient step-by-step synthesis of ketomethylenimino Psi[CO-CH=N] and ketomethylenamino [CO-CH2-NH] peptides. The key is the reaction between the free amino terminus of the supported peptide and a glyoxal-modified amino acid, leading to a ketomethylenimino bond, which can be reduced to a ketomethylenamino bond. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.164
• 作为产物：
  描述：

  Fmoc-L-valyl(diazo)methane 以 various solvent(s) 为溶剂， 反应 0.17h， 以100%的产率得到Fmoc-Val-CHO
  参考文献：
  名称：

  Efficient and direct solid phase synthesis of ketomethylenimino and ketomethylenamino peptides

  摘要：

  The aim of this study is the synthesis of pseudopeptides on solid supports, in order to quickly obtain modified peptides. We report a convenient step-by-step synthesis of ketomethylenimino Psi[CO-CH=N] and ketomethylenamino [CO-CH2-NH] peptides. The key is the reaction between the free amino terminus of the supported peptide and a glyoxal-modified amino acid, leading to a ketomethylenimino bond, which can be reduced to a ketomethylenamino bond. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.09.164

文献信息

• Efficient and direct solid phase synthesis of ketomethylenimino and ketomethylenamino peptides
  作者：Elise Bernard、Régis Vanderesse

  DOI：10.1016/j.tetlet.2004.09.164

  日期：2004.11

  The aim of this study is the synthesis of pseudopeptides on solid supports, in order to quickly obtain modified peptides. We report a convenient step-by-step synthesis of ketomethylenimino Psi[CO-CH=N] and ketomethylenamino [CO-CH2-NH] peptides. The key is the reaction between the free amino terminus of the supported peptide and a glyoxal-modified amino acid, leading to a ketomethylenimino bond, which can be reduced to a ketomethylenamino bond. (C) 2004 Elsevier Ltd. All rights reserved.