Substituted Isoindolones and Their Use as Metabotropic Glutamate Receptor Potentiators
申请人:VAN WAGENEN Bradford
公开号:US20110166155A1
公开(公告)日:2011-07-07
The present invention is directed to compounds of formula I:
wherein R
1
, R
2
, R
3
, R
4
, R
5
, R
6
, R
7
, R
8
, R
9
and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
本发明涉及式子I的化合物:其中R1,R2,R3,R4,R5,R6,R7,R8,R9和n的定义如本说明书中的式子I所述。本发明还涉及制备该化合物的工艺以及用于制备的新中间体,含有该化合物的药物组合物以及该化合物在治疗中的使用。