2-Ethenyl-1-methylpyridinium bromide | 34895-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Ethenyl-1-methylpyridinium bromide
• 英文别名: 2-ethenyl-1-methylpyridin-1-ium;bromide
• CAS: 34895-02-8
• 化学式: C8H10BrN
• 分子量: 200.08
• InChiKey: AYMALQIRXBTCAW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.84
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] MACROMOLECULAR PRODRUGS FOR HARD TISSUE AND METHODS OF USE THEREOF<br/>[FR] PROMÉDICAMENTS MACROMOLÉCULAIRES POUR TISSU DUR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：NEW YORK SOC RUPTURED & CRIPPLED MAINTAINING HOSPITAL FOR SPECIAL SURGERY

  公开号：WO2014036548A1

  公开（公告）日：2014-03-06

  Compositions for intravenous administration and methods for treating bone diseases, disorders, and fractures comprising macromolecular prodrugs of hydrophobic bone anabolic agents are provided. Specifically, novel macromolecular amphiphilic prodrugs wherein at least three molecules of simvastatin are conjugated to polyethylene glycol, which spontaneously form micelles in aqueous solutions are provided.

  提供用于静脉给药的组成物以及包括疏水性骨骼合成剂的巨分子前药治疗骨骼疾病、紊乱和骨折的方法。具体而言，提供新颖的巨分子两亲性前药，其中至少三分子辛伐他汀与聚乙二醇共轭，它们在水溶液中自发形成胶束。
• RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY
  申请人：UNIVERSITY OF UTAH RESEARCH FOUNDATION

  公开号：US20160166693A1

  公开（公告）日：2016-06-16

  Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti-cancer compounds are also described herein.

  本文描述了一种抗癌化合物，由包括（1）至少一种直接或间接与大分子结合的抗癌药物和（2）至少一种直接或间接与大分子结合的高Z元素组成，该高Z元素在暴露于X射线能量时能够产生奥古尔电子。当这些化合物暴露于低能量X射线（例如，千电子伏特KeV）时，化合物中存在的高Z元素会产生奥古尔电子。与使用百万电子伏特范围内的治疗性X射线能量（MeV）的典型放射疗法相比，所需的能量更低，因此受试者在与放射疗法相比时经历较低的附带损伤。此外，抗癌药物的存在提供了杀死癌细胞的第二机制。本文还描述了制备和使用抗癌化合物的方法。
• [EN] MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES<br/>[FR] SYSTEMES D'ADMINISTRATION MACROMOLECULAIRES DESTINES A L'IMAGERIE, A L'EVALUATION ET AU TRAITEMENT NON INVASIFS DE L'ARTHRITE ET D'AUTRES MALADIES INFLAMMATOIRES
  申请人：UNIV UTAH RES FOUND

  公开号：WO2005097073A1

  公开（公告）日：2005-10-20

  This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

  本发明涉及生物技术，更具体地说，涉及用于成像、评估和/或治疗类风湿性关节炎和其他炎症性疾病的水溶性高分子递送系统。利用现代磁共振成像技术，证明了大分子在大鼠佐剂诱导性关节炎中的关节特异性积累。MR对比剂标记的聚合物的摄取和保留与炎症和局部组织损伤的组织病理学特征之间的强相关性证明了本发明的高分子递送系统的实际应用。
• MOISTURE-SENSITIVE ELEMENT, MOISTURE-SENSITIVE MATERIAL AND MANUFACTURING METHOD FOR SAME
  申请人：Hitachi, Ltd.

  公开号：EP0057728A1

  公开（公告）日：1982-08-18

  A moisture-sensitive element composed of an insulating substrate (1), a pair of electrodes (2, 3) provided on the substrate, and moisture-sensitive material (8) covering the electrodes. The resistance of the moisture-sensitive material (8) depends on the moisture content of atmosphere, and it is made of corpuscles each of which is composed of a hydrophobic nucleus and a surface layer covering the nucleus which contains ionic or hydrophilic radicals. In this moisture-sensitive element, the relation between the logarithm of its electrical resistance and the relative humidity is nearly linear and it has small hysteresis, so that the relative humidity can be measured exactly. The insulating substrate (1) and the electrodes (2, 3) are preferably made of an insulating layer formed on a silicon semiconductor and conductive polysilicon formed thereon, respectively, so it can be miniaturized.

  一种湿度敏感元件，由绝缘基板（1）、基板上的一对电极（2、3）和覆盖电极的湿度敏感材料（8）组成。湿敏材料（8）的电阻取决于大气中的湿度，它是由一个个小球组成的，每个小球都由一个疏水核和一个覆盖在核上的表面层组成，表面层含有离子或亲水基。在这种湿敏元件中，其电阻的对数与相对湿度之间的关系近似线性，且滞后很小，因此可以准确测量相对湿度。绝缘基板（1）和电极（2、3）最好分别由在硅半导体上形成的绝缘层和在其上形成的导电多晶硅制成，这样可以使其小型化。
• Quaternary polyvinylpyrridinium derivatives as anti-dye transfer agents
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP1083218A1

  公开（公告）日：2001-03-14

  A water-soluble quaternary polyvinylpyrridinium derivative which inhibits dye transfer in detergent compositions without adversely affecting stain or soil removal or soil redeposition. The quaternary polyvinylpyrridinium derivative contains a quaternary nitrogen and an anionic moiety selected from a sulfonate and/or a carboxylate functionality, said quaternary polyvinylpyrridinium derivative having the structure wherein a, b, c, d, e, and f represent the mole percent of the respective repeating unit, a is 1 to 100, b is 0 to 99, c is 0 to 99, d is 0 to 99, e is 0 to 99; f is 0 to 99; R is selected from the group consisting of substituted or unsubstituted C1-C18 alkyl, C1-C18 alkenyl, C1-C18 alkoxy, C1-C18 aryl, and benzyl; R1, R2, and R3, are independently selected from the group consisting of hydrogen, hydroxyl, alkyl having C1 to C18, aryl having C6 to C18, and alkaryl having C7 to C18; Y is independently selected from the group consisting of (CR4R5)m1, benzene, and substituted benzene, wherein substituted benzene is independently a benzene substituted with a group selected from the group consisting of amino, nitro, halogen, and combinations thereof; R4 and R5 are independently hydrogen or hydroxyl; m1 is 0 to 10; Z is the residue of an ethylenically unsaturated monomer; M+ is independently a cation wherein M is selected from the group consisting of hydrogen ammonia, alkali metals, alkaline earth metals, zinc, copper, organic amines, amino acids, and amino saccharides; X- is independently a halide; and A- is independently a halide, provided that A- is present when M+ is present.

  一种水溶性季铵盐聚乙烯基吡啶鎓衍生物，可抑制洗涤剂组合物中的染料转移，而不会对去污或去垢或土壤再沉积产生不利影响。季铵盐聚乙烯基吡啶鎓衍生物含有一个季铵盐氮和一个选自磺酸盐和/或羧酸盐官能团的阴离子基团，所述季铵盐聚乙烯基吡啶鎓衍生物具有以下结构 其中 a、b、c、d、e 和 f 代表各自重复单元的摩尔百分比，a 为 1 至 100，b 为 0 至 99，c 为 0 至 99，d 为 0 至 99，e 为 0 至 99；f 为 0 至 99；R选自由取代或未取代的C1-C18烷基、C1-C18烯基、C1-C18烷氧基、C1-C18芳基和苄基组成的组；R1、R2和R3独立地选自由氢、羟基、C1-C18的烷基、C6-C18的芳基和C7-C18的烷芳基组成的组；Y 独立地选自由 (CR4R5)m1、苯和取代的苯组成的组；其中取代的苯独立地是被选自由氨基、硝基、卤素和它们的组合组成的组取代的苯；R4 和 R5 独立地是氢或羟基；m1 是 0 至 10；Z 是乙烯基不饱和单体的残留物；M+ 独立地是阳离子，其中 M 选自氢氨、碱金属、碱土金属、锌、铜、有机胺、氨基酸和氨基糖组成的组；X- 独立地是卤化物；A- 独立地是卤化物，条件是当 M+ 存在时 A- 也存在。