(2,3,5,6-tetrafluoro-4-methylphenyl)methyl (1S,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropane-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3,5,6-tetrafluoro-4-methylphenyl)methyl (1S,3S)-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropane-1-carboxylate
• 化学式: C₁₇H₁₄ClF₇O₂
• 分子量: 418.7
• InChiKey: ZFHGXWPMULPQSE-PSASIEDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol
  申请人：——

  公开号：US20040063993A1

  公开（公告）日：2004-04-01

  A process for the preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol comprising hydrogenating 4-methyl-2,3,5,6-tetrafluorobenzonitrile to 4-methyl-2,3,5,6-tetrafluorobenzylamine and converting 4-methyl-2,3,5,6-tetrafluorobenzylamine to 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol. The process optionally also comprises the further step of reacting 4-Methyl-2,3,5,6-tetrafluobenzyl alcohol with cis-Z-3-(2-chloro-1,1,1-trifluoro-2-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride to the form tefluthrin. 4-Methyl-2,3,5,6-tetrafluorobenzylamine and salts thereof are also claimed.

  一种制备4-甲基-2,3,5,6-四氟苯甲醇的方法，包括将4-甲基-2,3,5,6-四氟苯甲腈加氢制得4-甲基-2,3,5,6-四氟苯甲胺，然后将4-甲基-2,3,5,6-四氟苯甲胺转化为4-甲基-2,3,5,6-四氟苯甲醇。该方法还可以包括将4-甲基-2,3,5,6-四氟苯甲醇与顺式-Z-3-(2-氯-1,1,1-三氟-2-丙烯基)-2,2-二甲基环丙烷羧酰氯反应以形成特氟氰。同时还声明了4-甲基-2,3,5,6-四氟苯甲胺及其盐。
• Preparation of 4-methyl-2, 3, 5, 6-tetrafluorobenzyl alcohol
  申请人：Jones Heavon Raymond Vincent

  公开号：US20050054886A1

  公开（公告）日：2005-03-10

  A process for the preparation of 1,4-bis(hydroxymethyl)-2,3,5,6-tetrafluorobenzene comprising fluorinating 2,3,5,6-tetrachloroterephthalonitrile to obtain 2,3,5,6-tetrafluoroterephthalonitrile, hydrogenating 2,3,5,6-tetrafluoroterephthalonitrile to give 1,4-bis(aminomethyl)-2,3,5,6-tetrafluorobenzene and converting 1,4-bis(aminomethyl)-2,3,5,6-tetrafluorobenzene to 1,4-bis(hydroxymethyl)-2,3,5,6-tetrafluorobenzene.

  制备1,4-双(羟甲基)-2,3,5,6-四氟苯的过程包括氟化2,3,5,6-四氯对苯二腈以获得2,3,5,6-四氟对苯二腈，将2,3,5,6-四氟对苯二腈氢化以得到1,4-双(氨甲基)-2,3,5,6-四氟苯，并将1,4-双(氨甲基)-2,3,5,6-四氟苯转化为1,4-双(羟甲基)-2,3,5,6-四氟苯。
• PYRETHROID FORMULATIONS OF REDUCED PARESTHESIA
  申请人：ICI AMERICAS INC.

  公开号：EP0538246A1

  公开（公告）日：1993-04-28
• PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL
  申请人：Syngenta Limited

  公开号：EP1332125B1

  公开（公告）日：2004-09-29
• US6894195B2
  申请人：——

  公开号：US6894195B2

  公开（公告）日：2005-05-17