1,5-Dimethyl-6-oxopyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,5-Dimethyl-6-oxopyridine-3-carboxamide
• 英文别名: 1,5-dimethyl-6-oxopyridine-3-carboxamide
• 化学式: C₈H₁₀N₂O₂
• 分子量: 166.18
• InChiKey: JODAECAZANNFLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Method of inducing beta cells from urine-derived cells using small molecules
  申请人：UNIVERSITY OF SOUTH AUSTRALIA

  公开号：US10752884B2

  公开（公告）日：2020-08-25

  The disclosure relates to a method of producing induced beta cells from urine-derived cells, the method comprising providing urine-derived cells; inducing the urine-derived cells by culturing said urine-derived cells in a primary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a first period of time to obtain induced endoderm cells; inducing the induced endoderm cells by culturing said induced endoderm cells in a secondary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a second period of time to obtain induced pancreatic precursor cells; and inducing the induced pancreatic precursor cells by culturing said pancreatic precursor cells in a tertiary induction culture medium comprising an effective amount of at least one small molecule reprogramming factor(s) for a third period of time to obtain induced beta cells.

  本公开涉及一种从尿液衍生细胞生产诱导β细胞的方法，该方法包括提供尿液衍生细胞；通过在包含有效量的至少一种小分子重编程因子的初级诱导培养基中培养所述尿液衍生细胞一段时间来诱导尿液衍生细胞，以获得诱导内胚层细胞；在含有有效量的至少一种小分子重编程因子的二级诱导培养基中培养诱导的内胚层细胞一段时间，以获得诱导的胰腺前体细胞；以及在含有有效量的至少一种小分子重编程因子的三级诱导培养基中培养诱导的胰腺前体细胞一段时间，以获得诱导的β细胞。
• NOVEL ANTIFUNGAL OXODIHYDROPYRIDINECARBOHYDRAZIDE DERIVATIVE
  申请人：Daewoong Pharmaceutical Co., Ltd.

  公开号：EP3060549B1

  公开（公告）日：2019-02-13