N-苄基-4-甲基戊-2-胺 | 60509-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-苄基-4-甲基戊-2-胺
• 英文名称: benzyl(1,3-dimethylbutyl)amine
• 英文别名: N-(1,3-dimethylbutyl)benzylamine；1.3-Dimethylbutylbenzylamin；Benzenemethanamine, N-(1,3-dimethylbutyl)-；N-benzyl-4-methylpentan-2-amine
• CAS: 60509-76-4
• 化学式: C₁₃H₂₁N
• mdl: MFCD07473539
• 分子量: 191.316
• InChiKey: JFQMTBSPRNVCJU-UHFFFAOYSA-N

物化性质

• 沸点：
  259.3±9.0 °C(Predicted)
• 密度：
  0.892±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(1,3-dimethylbutylidene)benzylamine 在 aluminum isopropoxide 、 镍 、 异丙醇 作用下， 以 xylene 为溶剂， 反应 48.0h， 以10%的产率得到N-苄基-4-甲基戊-2-胺
  参考文献：
  名称：

  Alcohols and aluminum alkoxides in the presence of Raney nickel as alkylating agents. 3. Reduction of Schiff bases with isopropyl alcohol and aluminum isopropoxide in the presence of Raney nickel

  摘要：

  DOI：

  10.1021/jo00211a026

文献信息

• Rhodium(<scp>I</scp>)–sulfonated-bdpp catalysed asymmetric hydrogenation of imines in aqueous–organic two-phase solvent systems
  作者：József Bakos、Árpád Orosz、Bálint Heil、Mohamed Laghmari、Paul Lhoste、Denis Sinou

  DOI：10.1039/c39910001684

  日期：——

  The imines ArC(Me)NCH2Ph (Ar = Ph, 2-MeO-C6H4, 3-MeO-C6H4, 4-MeO-C6H4) are hydrogenated to the corresponding amines with extremely high enantioselectivities up to 96% under very mild conditions, using rhodium complexes associated with sulfonated bdpp.

  利用与磺化 bdpp 相关联的铑络合物，在非常温和的条件下将亚胺 ArC(Me)NCH2Ph（Ar = Ph、2-MeO-C6H4、3-MeO-C6H4、4-MeO-C6H4）氢化为相应的胺，对映体选择性极高，可达 96%。
• Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
  申请人：Zhu Yun-Fei

  公开号：US20070208049A1

  公开（公告）日：2007-09-06

  GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R 1 , R 2 , R 3a , R 3b , R 4 , R 5 , R 6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

  本发明揭示了GnRH受体拮抗剂，其在治疗男女性激素相关疾病方面具有用途。本发明的化合物具有以下结构：其中A、Q、R1、R2、R3a、R3b、R4、R5、R6和n的定义如本文所述，包括立体异构体、前药和其药学上可接受的盐。本发明还揭示了含有本发明化合物与药学上可接受的载体组合的组合物，以及与其相关的方法，用于在需要时对抗促性腺激素释放激素。
• One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions
  作者：Shinya Sato、Takeshi Sakamoto、Etsuko Miyazawa、Yasuo Kikugawa

  DOI：10.1016/j.tet.2004.06.045

  日期：2004.8

  A one-pot reductive amination of aldehydes and ketones with amines using alpha-picoline-borane as a reducing agent is described. The reaction has been carried out in Wolf, in H2O, and in neat conditions in the presence of small amounts of AcOH. This is a highly efficient and mild procedure that is applicable for a wide variety of substrates. In particular, this is the first successful demonstration that this type of reaction can be carried out in water and in neat conditions. (C) 2004 Elsevier Ltd. All rights reserved.
• A mild, pyridine-borane-based reductive amination protocol
  作者：Mark D. Bomann、Ian C. Guch、Marcello DiMare

  DOI：10.1021/jo00123a049

  日期：1995.9
• JP2005/170917
  申请人：——

  公开号：——

  公开（公告）日：——