1-ethyl-6-methyl-3-[(E)-2-phenylethenyl]-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-ethyl-6-methyl-3-[(E)-2-phenylethenyl]-1H,5H,6H,7H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione
• 英文别名: 1-ethyl-6-methyl-3-[(E)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7-dione
• 化学式: C₁₆H₁₅N₅O₂
• 分子量: 309.327
• InChiKey: BMHKZVDHCKLDME-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
  申请人：Petry Stefan

  公开号：US20080032984A1

  公开（公告）日：2008-02-07

  The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diones, pharmaceutically acceptable salts thereof and physiologically functional derivatives. The invention therefore relates to compounds of the formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are suitable for use as antidiabetics, for example.

  该发明涉及嘧啶并[5,4-e][1,2,4]三嗪-5,7-二酮，其药学上可接受的盐和生理功能衍生物。因此，该发明涉及式I的化合物，其中基团具有所给定的含义，以及它们的生理耐受盐和制备它们的过程。这些化合物适用于例如作为抗糖尿病药物。
• PYRIMIDO 5,4-e 1,2,4 TRIAZIN-5,7-DIONE, VERF AHREN ZU DEREN HERSTELLUNG UND DEREN VERWENDUNG
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1587806B1

  公开（公告）日：2008-11-12
• COMPOUNDS AND METHODS FOR TREATING TUBERCULOSIS INFECTION
  申请人：Wong Chi-Huey

  公开号：US20130158037A1

  公开（公告）日：2013-06-20

  The present invention provides compounds which are potent inhibitors against Lpd activity, PDH activity, and/or the growth of tubercle bacillus , and thus are useful in the treatment of tuberculosis infection and associated conditions. The present invention is further directed to in vitro- and in vzivo-based methods of inhibiting Lpd and/or PDH activity. In certain embodiments, these methods are useful in inhibiting Lpd and/or PDH activity key to a pathogen's survival.
• US7737144B2
  申请人：——

  公开号：US7737144B2

  公开（公告）日：2010-06-15
• US9073941B2
  申请人：——

  公开号：US9073941B2

  公开（公告）日：2015-07-07