[(Z)-1-(4-fluorophenyl)-2-(1-methylbenzimidazol-2-yl)ethenyl] 4-fluorobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(Z)-1-(4-fluorophenyl)-2-(1-methylbenzimidazol-2-yl)ethenyl] 4-fluorobenzoate
• 化学式: C₂₃H₁₆F₂N₂O₂
• 分子量: 390.4
• InChiKey: SBKMTBNACNYRHF-STZFKDTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• BENZIMIDAZOLES AS COOLING COMPOUNDS
  申请人：Givaudan SA

  公开号：EP2040666B1

  公开（公告）日：2010-01-20
• Benzimidazole As Cooling Compounds
  申请人：Furrer Stefan Michael

  公开号：US20090312384A1

  公开（公告）日：2009-12-17

  A method of providing a cooling sensation to the skin or mucous membranes of the mouth by applying thereto a quantity of at least one chemical compound sufficient to cause a desirable degree of cooling sensation, the chemical compound comprising a compound of formula I: in which R 1 , R 2 are independently in either the meta- or para-position and independently comprise at least one of hydrogen, halide, C 1 -C 3 alkyl (linear or branched), halide, C 1 -C 3 alkoxy, nitro, nitrile, amide or ester; R 3 comprises at least one of C 1 -C 5 alkyl or C 1 -C 5 alkenyl groups (linear or branched), R 4 comprises at least one of hydrogen, C 1 -C 3 alkyl (linear or branched), or a halide. The cooling effect provided is in some instances superior to that achievable by any of the known commercial cooling agents.