7-chloro-3-methyl-2-[4-(2-hydroxyethyl)-1-piperazinylcarbonyl]-4H-1,4-benzothiazine | 1332599-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 7-chloro-3-methyl-2-[4-(2-hydroxyethyl)-1-piperazinylcarbonyl]-4H-1,4-benzothiazine
• 英文别名: (7-chloro-3-methyl-4H-1,4-benzothiazin-2-yl)-[4-(2-hydroxyethyl)piperazin-1-yl]methanone
• CAS: 1332599-06-0
• 化学式: C₁₆H₂₀ClN₃O₂S
• 分子量: 353.873
• InChiKey: QJIXREXQJCGLET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  81.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-5-氯噻吩 在 二甲基亚砜 作用下， 以 甲醇 、 异丙醇 为溶剂， 反应 0.42h， 生成 7-chloro-3-methyl-2-[4-(2-hydroxyethyl)-1-piperazinylcarbonyl]-4H-1,4-benzothiazine
  参考文献：
  名称：

  Synthesis and antimicrobial activity of morpholinyl/piperazinylbenzothiazines

  摘要：

  Structurally diverse morpholinyl/piperazinylbenzothiazines have been synthesized in quantitative yields by the reaction of substituted 1,4-benzothiazines with morpholine/N-(2-hydroxyethyl)piperazine. 1,4-Benzothiazines were prepared by the reaction of substituted 2-aminobenzenethiols with beta-ketoesters. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. Some of the synthesized compounds have shown significant activity against microorganisms.

  DOI：

  10.1007/s00044-011-9732-z

文献信息

• Synthesis and antimicrobial activity of morpholinyl/piperazinylbenzothiazines
  作者：Praveen Kumar Sharma、M. Kumar、Sharad Vats

  DOI：10.1007/s00044-011-9732-z

  日期：2012.8

  Structurally diverse morpholinyl/piperazinylbenzothiazines have been synthesized in quantitative yields by the reaction of substituted 1,4-benzothiazines with morpholine/N-(2-hydroxyethyl)piperazine. 1,4-Benzothiazines were prepared by the reaction of substituted 2-aminobenzenethiols with beta-ketoesters. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. Some of the synthesized compounds have shown significant activity against microorganisms.