propyl 2-chloro-5-[5-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: propyl 2-chloro-5-[5-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoate
• 化学式: C₁₈H₁₄ClNO₄S₂
• 分子量: 407.9
• InChiKey: ZWVRQKCTVZQGFV-DHDCSXOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] A HIGH-THROUGHPUT ASSAY FOR IDENTIFYING SMALL MOLECULES THAT MODULATE AMP-ACTIVATED PROTEIN KINASE (AMPK)<br/>[FR] DOSAGE À HAUT RENDEMENT POUR IDENTIFIER DE PETITES MOLÉCULES QUI MODULENT LA PROTÉINE KINASE ACTIVÉE PAR L'AMP (AMPK)
  申请人：UNIV NORTH CAROLINA

  公开号：WO2016025023A1

  公开（公告）日：2016-02-18

  The present invention provides an in vitro method for identifying a compound that modulates adenosine monophosphate-activated protein kinase (AMPK) for the manufacture of a diagnostic or therapeutic agent. The present invention further provides an assay for identifying a compound that modulates AMPK.

  本发明提供了一种体外方法，用于鉴定调节腺苷单磷酸激活蛋白激酶（AMPK）的化合物，以制造诊断或治疗剂。本发明进一步提供了一种用于鉴定调节AMPK的化合物的检测方法。
• High-Throughput Assay for Identifying Small Molecules that Modulate AMP-activated Protein Kinase (AMPK)
  申请人：North Carolina Central University

  公开号：US20160176859A1

  公开（公告）日：2016-06-23

  The present invention provides an in vitro method for identifying a compound that modulates adenosine monophosphate-activated protein kinase (AMPK) for the manufacture of a diagnostic or therapeutic agent. The present invention further provides an assay for identifying a compound that modulates AMPK.

  本发明提供了一种体外方法，用于鉴定调节腺苷酸单磷酸激活蛋白激酶（AMPK）的化合物，以制备诊断或治疗制剂。本发明还提供了一种用于鉴定调节AMPK的化合物的测定方法。
• PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING OSTEOARTHRITIS, CONTAINING RHODANINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Avixgen Inc.

  公开号：EP3827827A1

  公开（公告）日：2021-06-02

  The present disclosure relates to the use of a rhodanine derivative in the prevention, amelioration or treatment of osteoarthritis. The rhodanine derivative according to the present disclosure has excellent effects of rescuing the loss of the cartilage matrix and alleviating synovitis, and thus may be effectively used for the prevention, amelioration or treatment of osteoarthritis.

  本公开涉及一种罗丹宁衍生物在预防、改善或治疗骨关节炎中的用途。根据本公开的罗丹宁衍生物在挽救软骨基质的损失和缓解滑膜炎方面具有极佳的效果，因此可有效地用于预防、改善或治疗骨关节炎。
• [EN] A HIGH-THROUGHPUT ASSAY FOR IDENTIFYING SMALL MOLECULES THAT MODULATE AMP-ACTIVATED PROTEIN KINASE (AMPK)<br/>[FR] DOSAGE À HAUT DÉBIT PERMETTANT D'IDENTIFIER DE PETITES MOLÉCULES QUI MODULENT LA PROTÉINE KINASE ACTIVÉE PAR AMP (AMPK)
  申请人：UNIV NORTH CAROLINA

  公开号：WO2015023827A1

  公开（公告）日：2015-02-19

  The present invention provides an in vitro method for identifying a compound that modulates adenosine monophosphate-activated protein kinase (AMPK) for the manufacture of a diagnostic or therapeutic agent. The present invention further provides an assay for identifying a compound that modulates AMPK.