5-[(4-fluorophenyl)methyl]-1H-pyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[(4-fluorophenyl)methyl]-1H-pyrazole
• 化学式: C₁₀H₉FN₂
• 分子量: 176.19
• InChiKey: BTSMSLADPMSLDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP4025574A1

  公开（公告）日：2022-07-13
• [EN] RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME<br/>[FR] COMPOSÉS INHIBITEURS DE RIP1 ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2021046407A1

  公开（公告）日：2021-03-11

  Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.