N'-acetyl-3-chloro-N-[2-(diethylamino)ethyl]benzohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-acetyl-3-chloro-N-[2-(diethylamino)ethyl]benzohydrazide
• 化学式: C₁₅H₂₂ClN₃O₂
• 分子量: 311.81
• InChiKey: BBEACRZMCNWXIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF CYSTINE-GLUTAMATE TRANSPORTER FOR USE IN TREATING OR PREVENTING SUBSTANCE-RELATED AND ADDICTIVE DISORDERS
  申请人：China Medical University

  公开号：EP3302493B1

  公开（公告）日：2021-07-07
• NEW USE OF INHIBITOR OF CYSTINE-GLUTAMATE TRANSPORTER
  申请人：CHINA MEDICAL UNIVERSITY

  公开号：US20180153865A1

  公开（公告）日：2018-06-07

  The invention surprisingly found that agents that inhibit system x c − provide the therapeutic intervention in substance-related and addictive disorders and the treatment and/or prevention in substance-mediated brain damage and confirms that system x c − is a promising therapeutic target for substance-induced addiction and brain damage.
• METHODS AND COMBINATIONS FOR MODULATING TOLERANCE TO OPIATES, OPIOIDS OR OPIOID ANALGESICS AND TREATING ACUTE AND CHRONIC PAIN
  申请人：CHINA MEDICAL UNIVERSITY

  公开号：US20210177869A1

  公开（公告）日：2021-06-17

  The present disclosure provides methods for modulating tolerance to opiates, opioids or opioid analgesics and/or treating acute and chronic pain and/or decreasing opiate or opioid-induced side effects. Also provided is a combination comprising a therapeutically effective amount, or a sub-therapeutically effective amount, of opiate, opioid or opioid analgesic and a therapeutically effective amount of a cystine/glutamate antiporter system x c − inhibitor.