3-Hydroxy-2-phenylmethoxypentanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Hydroxy-2-phenylmethoxypentanoic acid
• 英文别名: 3-hydroxy-2-phenylmethoxypentanoic acid
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.25
• InChiKey: LCLUQLMDCJVZIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] ENGINEERED POLYPEPTIDES AND THEIR APPLICATIONS IN SYNTHESIS OF BETA-HYDROXY-ALPHA-AMINO ACIDS<br/>[FR] POLYPEPTIDES MODIFIÉS ET LEURS APPLICATIONS DANS LA SYNTHÈSE D'ACIDES BÊTA-HYDROXY-ALPHA-AMINÉS
  申请人：ENZYMASTER NINGBO BIO ENG CO LTD

  公开号：WO2018219107A1

  公开（公告）日：2018-12-06

  Provided are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed are developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R) -2-amino-3-hydroxy-3- (4-nitrophenyl) propanoic acid. Also provided are polynucleotides encoding the engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. It has good industrial application prospects.

  提供了经过工程改造的多肽，可用于在工业相关条件下不对称合成β-羟基-α-氨基酸。所述经过改造的多肽是通过基于催化合成（2S，3R）-2-氨基-3-羟基-3-（4-硝基苯基）丙酸的能力进行定向进化而开发的。还提供了编码经过改造的多肽的多核苷酸、能够表达经过改造的多肽的宿主细胞，以及使用经过改造的多肽生产β-羟基-α-氨基酸的方法。与其他制备过程相比，使用经过改造的多肽制备β-羟基-α-氨基酸可得到所需立体异构体的高纯度，反应条件温和，污染和能耗低。具有良好的工业应用前景。
• [EN] ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF<br/>[FR] POLYPEPTIDES ALDOLASE MODIFIÉS ET LEURS UTILISATIONS
  申请人：ENZYMASTER NINGBO BIO ENG CO LTD

  公开号：WO2018219108A1

  公开（公告）日：2018-12-06

  Provided herein are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. Also provided are polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption.

  本文提供了一些工程多肽，可在工业相关条件下用于β-羟基-α-氨基酸的不对称合成。还提供了编码工程多肽的多核苷酸、能够表达工程多肽的宿主细胞以及使用工程多肽生产β-羟基-α-氨基酸的方法。与其他制备过程相比，使用工程多肽制备β-羟基-α-氨基酸可获得所需立体异构体的高纯度、温和的反应条件、低污染和低能耗。
• ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF
  申请人：Enzymaster (Ningbo) Bio-Engineering Co., Ltd.

  公开号：EP3630795A1

  公开（公告）日：2020-04-08
• ENGINEERED POLYPEPTIDES AND THEIR APPLICATIONS IN SYNTHESIS OF BETA-HYDROXY-ALPHA-AMINO ACIDS
  申请人：Enzymaster (Ningbo) Bio-Engineering Co., Ltd.

  公开号：EP3630798A1

  公开（公告）日：2020-04-08