1,1-diethyl-pentylamine | 76613-36-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-diethyl-pentylamine
• 英文别名: 3-Aethyl-3-amino-heptan；1,1-Diaethyl-pentylamin；3-Ethylheptan-3-amine
• CAS: 76613-36-0
• 化学式: C₉H₂₁N
• 分子量: 143.272
• InChiKey: JFKXMFQLKZLMLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-diethyl-pentylamine 在 磺酰氯 、 次氯酸叔丁酯 、 sodium hydride 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 N,N'-bis(1,1-diethylpentyl)thiadiaziridine 1,1-dioxide
  参考文献：
  名称：

  Thiadiaziridine 1,1-dioxides: synthesis and chemistry

  摘要：

  DOI：

  10.1021/jo00323a021
• 作为产物：
  描述：

  3-乙基-3-庚醇 在 lithium aluminium tetrahydride 、 sodium azide 、 硫酸 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 61.0h， 生成 1,1-diethyl-pentylamine
  参考文献：
  名称：

  Thiadiaziridine 1,1-dioxides: synthesis and chemistry

  摘要：

  DOI：

  10.1021/jo00323a021

文献信息

• ANTIMICROBIAL CATIONIC POLYCARBONATES
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20140301967A1

  公开（公告）日：2014-10-09

  Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

  具有一个或两个阳离子聚碳酸酯链的抗菌阳离子聚合物是通过有机催化的环氧开聚合制备的。其中一种抗菌阳离子聚合物具有基本由阳离子碳酸酯重复单元构成的聚合物链，与一个或两个末端基团相连。末端基团可以包括胆固醇等生物活性化合物的共价结合形式。其他抗菌阳离子聚合物具有随机共聚碳酸酯链，其中含有少量疏水重复单元，带有维生素E和/或维生素D2的共价结合形式。这些阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。
• [EN] COMPOUNDS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DE LA FIBROSE KYSTIQUE
  申请人：UNIV MISSOURI

  公开号：WO2019136314A1

  公开（公告）日：2019-07-11

  Provided are compounds having Formula (1), compositions thereof, and methods of modulating CFTR activity. Also provided are methods of treating a condition associated with decreased CFTR activity comprising administering to a subject an effective amount of a compound of Formula (1), optionally with other therapeutic agent(s).

  提供了具有化学式（1）的化合物，其组合物以及调节CFTR活性的方法。还提供了治疗与CFTR活性降低相关的疾病的方法，包括向受试者施用化合物的有效量的化合物（1），可选择性地与其他治疗剂一起使用。
• VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US20180117162A1

  公开（公告）日：2018-05-03

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).

  制备了包含以下组成部分的凝胶形成嵌段共聚物：i）主要由二价聚乙二醇链组成的中心亲水性块和ii）通过带有一个或多个氢键形成*—N(H)—*基团连接到中心块的两个外周单碳酸酯或多碳酸酯疏水性块。疏水性块包含一个或多个含维生素的亚单位。这些凝胶形成嵌段共聚物可用于制备各种可生物降解和/或生物相容的水凝胶和有机凝胶药物组合物，特别是抗微生物和/或抗肿瘤药物组合物。水凝胶组合物在药物输送的库存注射中具有实用性。与由聚乙二醇制备的类似水凝胶相比，氢键*—N(H)—*基团提供了凝胶在体内降解之前更长的生命周期，以及与水凝胶相比更延长和控制释放速率的疏水性药物。
• Ionic Liquids for Separation of Olefin-Paraffin Mixtures
  申请人：Dai Sheng

  公开号：US20110015461A1

  公开（公告）日：2011-01-20

  The invention is directed to an ionic liquid comprising (i) a cationic portion containing a complex of a silver (I) ion and one or more neutral ligands selected from organoamides, organoamines, olefins, and organonitriles, and (ii) an anionic portion having the chemical formula wherein m and n are independently 0 or an integer of 1 or above, and p is 0 or 1, provided that when p is 0, the group —N—SO 2 —(CF 2 ) n CF 3 subtended by p is replaced with an oxide atom connected to the shown sulfur atom. The invention is also directed to a method for separating an olefin from an olefin-paraffin mixture by passing the mixture through a layer of the ionic liquid described above.

  该发明涉及一种离子液体，包括（i）含有银（I）离子的阳离子部分，该离子与来自有机酰胺、有机胺、烯烃和有机腈中选择的一个或多个中性配体形成的络合物，以及（ii）具有化学式的阴离子部分，其中m和n独立地为0或大于1的整数，p为0或1，但当p为0时，由p支撑的基团—N—SO2—(CF2)nCF3将被连接到所示硫原子的氧原子替代。该发明还涉及一种从烯烃烷烃混合物中分离烯烃的方法，通过将混合物经过上述离子液体的一层来实现。
• Preparation of new chiral diene ligands and their use in the rhodium catalyzed asymmetric annulation of 2-formylarylboronic acid with dialkylalkynes
  作者：Yu Sun、Yuanmeng Li、Xiuqi Wang、Xu Cao、Hongping Deng、Xiaoli Bu、Mengtao Ma、Fei Xue

  DOI：10.1039/d3cc02330c

  日期：——

  Herein, we report the rhodium-catalyzed domino arylation/cyclization reaction of unactivated internal alkynes to afford the optically active indenols in excellent yields (up to 92%) and extremely high enantioselectivities (up to 99% ee) in the presence of new amide substituted chiral diene ligands. Notably, a total of 21 new chiral diene ligands are synthesized, which are potential choices for other

  在此，我们报道了未活化内部炔烃的铑催化多米诺芳基化/环化反应，在新酰胺取代的存在下以优异的产率（高达 92%）和极高的对映选择性（高达 99% ee）提供光学活性茚醇手性二烯配体。值得注意的是，总共合成了 21 个新的手性二烯配体，它们是其他不对称反应的潜在选择。