1-(2-Azidophenyl)-1-hydroxypyrrolidin-1-ium-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Azidophenyl)-1-hydroxypyrrolidin-1-ium-2,5-dione
• 英文别名: 1-(2-azidophenyl)-1-hydroxypyrrolidin-1-ium-2,5-dione
• 化学式: C10H9N4O3+
• 分子量: 233.2
• InChiKey: KQFQILTZXNNHGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  68.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• OXIME CONJUGATES AND METHODS FOR THEIR FORMATION AND USE
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP1534269A1

  公开（公告）日：2005-06-01
• GP120 SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF
  申请人：Sloan-Kettering Institute For Cancer Research

  公开号：EP1569955A2

  公开（公告）日：2005-09-07
• PROSTATE SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF.
  申请人：Sloan-Kettering Institute For Cancer Research

  公开号：EP1570056A2

  公开（公告）日：2005-09-07
• [EN] OXIME CONJUGATES AND METHODS FOR THEIR FORMATION AND USE<br/>[FR] CONJUGUES D'OXIME ET LEUR PROCEDES DE FORMATION ET LEUR UTILISATION
  申请人：GEN HOSPITAL CORP

  公开号：WO2004009082A1

  公开（公告）日：2004-01-29

  The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for treating animals by administration of biodegradable biocompatible polyketals. In one aspect, a method for forming the biodegradable biocompatible polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a reducing agent to form the biodegradable biocompatible polyketal. The resultant biodegradable biocompatible polyketals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating animals includes the administration of the biodegradable biocompatible polyketal in which biologically active compounds or diagnostic labels can be disposed. The present invention also relates to chiral polyketals, methods for their preparation, and methods for use in chromatographic applications, specifically in chiral separations. A method for forming the chiral polyketals comprises combining a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate, which is combined with a suitable reagent to form the chiral polyketal. A method for use in chiral separations includes the incorporation of the chiral polyketals in the mobile phase during a chromatographic separation, or into chiral stationary phases such as gels. The present invention further relates to chiral polyketals as a source for chiral compounds, and methods for generating such chiral compounds.
• [EN] GP120 SPECIFIC ANTIGENS, CONJUGATES THEREOF, METHODS FOR THEIR PREPARATION AND USES THEREOF<br/>[FR] ANTIGENES SPECIFIQUES GP120, LEURS CONJUGUES, LEUR PROCEDES DE PREPARATION ET LEUR UTILISATION
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2004050711A2

  公开（公告）日：2004-06-17

  The present invention provides compounds having formula (I): wherein Rl, R2A, R2B, R3, R4, W1 , W2 and W3 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods of use thereof in the treatment of HIV, methods for the prevention of HIV, and methods for inducing HIV-specific antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a gp 120 glycan or glycopeptide of the invention.