N-phenylcarbamoyl-4-methylpiperidine | 57754-88-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenylcarbamoyl-4-methylpiperidine
• 英文别名: 4-methyl-N-phenylpiperidine-1-carboxamide
• CAS: 57754-88-8
• 化学式: C₁₃H₁₈N₂O
• mdl: MFCD00023699
• 分子量: 218.299
• InChiKey: GIAPKBPEDIJWCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-氯丙氧基)-2-甲基丙酰氯 、 N-phenylcarbamoyl-4-methylpiperidine 反应 6.0h， 生成 N-[2-(4-chlorophenoxy)-2-methyl]propionyl-N-phenyl-4-methylpiperidine-1-carboxamide
  参考文献：
  名称：

  N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with anti-inflammatory and anti-proliferative activities

  摘要：

  Six series of N-acyl-N-phenyl ureas 1-6 of piperidine (1), and 2-ethyl- (2), 3-methyl- (3), 4-methyl- (4), 4-phenyl- (5), cis-2,6-dimethyl- (6) piperidine were synthesised and evaluated for their anti-inflammatory, anaesthetic, anti-pyretic properties. Some derivatives of series 1 and 5 were also assayed for anti-proliferative activity. Several compounds showed an anti-inflammatory activity comparable or slighty inferior to that of indomethacin in rats (1c,d, 2a,b,g,h, 36, 4h, 5d,e). Moreover, an appreciable anti-inflammatory activity was also found in 2c,e, 3e,f,g, 4g, 5a,b,c,f,h, and 6a,b,d. All the compounds were devoid of anti-pyretic activity and only a few of them exhibited a low level of infiltration anaesthesia in mice. Compound 5a showed a broad spectrum anti-cancer activity (at low micromolar concentrations), particulary significant against leukemia subpanel. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01120-x
• 作为产物：
  描述：

  4-甲基哌啶 、 异氰酸苯酯 在 吡啶 作用下， 反应 0.17h， 生成 N-phenylcarbamoyl-4-methylpiperidine
  参考文献：
  名称：

  N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with anti-inflammatory and anti-proliferative activities

  摘要：

  Six series of N-acyl-N-phenyl ureas 1-6 of piperidine (1), and 2-ethyl- (2), 3-methyl- (3), 4-methyl- (4), 4-phenyl- (5), cis-2,6-dimethyl- (6) piperidine were synthesised and evaluated for their anti-inflammatory, anaesthetic, anti-pyretic properties. Some derivatives of series 1 and 5 were also assayed for anti-proliferative activity. Several compounds showed an anti-inflammatory activity comparable or slighty inferior to that of indomethacin in rats (1c,d, 2a,b,g,h, 36, 4h, 5d,e). Moreover, an appreciable anti-inflammatory activity was also found in 2c,e, 3e,f,g, 4g, 5a,b,c,f,h, and 6a,b,d. All the compounds were devoid of anti-pyretic activity and only a few of them exhibited a low level of infiltration anaesthesia in mice. Compound 5a showed a broad spectrum anti-cancer activity (at low micromolar concentrations), particulary significant against leukemia subpanel. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01120-x

文献信息

• PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS
  申请人：Urade Yoshihiro

  公开号：US20130165438A1

  公开（公告）日：2013-06-27

  The present invention provides a piperidine compound represented by Formula (I) (wherein X 1 , X 2 , X 2 , A, B and N are as defined in the Description); or a salt thereof.

  本发明提供了一种由化学式（I）表示的哌啶化合物（其中X1、X2、X2、A、B和N如描述中所定义）；或其盐。
• MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF
  申请人：BOTHMANN Hendrick

  公开号：US20100016288A1

  公开（公告）日：2010-01-21

  Compounds with α7 nicotinic acetylcholine receptor (α7 nAChR) agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric diseases.

  具有α7尼古丁型乙酰胆碱受体（α7 nAChR）激动活性的化合物，它们的制备方法，含有这些化合物的药物组合物以及用于治疗神经系统和精神疾病的用途。
• DERIVES D'OXOPIPERIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
  申请人：Sanofi-Aventis

  公开号：EP1773796B1

  公开（公告）日：2010-03-03
• CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS
  申请人：C4 Therapeutics, Inc.

  公开号：US20210009559A1

  公开（公告）日：2021-01-14

  The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein.
• US3972707A
  申请人：——

  公开号：US3972707A

  公开（公告）日：1976-08-03