N-苯基-N-[1-(1-苯基丙烷-2-基)哌啶-4-基]乙酰胺 | 101860-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-苯基-N-[1-(1-苯基丙烷-2-基)哌啶-4-基]乙酰胺
• 英文名称: Acetyl-alpha-methylfentanyl
• 英文别名: N-phenyl-N-[1-(1-phenylpropan-2-yl)piperidin-4-yl]acetamide
• CAS: 101860-00-8
• 化学式: C₂₂H₂₈N₂O
• 分子量: 336.5
• InChiKey: OKTLVZBUKMRPLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• METHODS AND DEVICES FOR COMPOUND DELIVERY
  申请人：E-Nicotine Technology, Inc.

  公开号：EP2925395A1

  公开（公告）日：2015-10-07
• METHODS AND COMPOSITIONS FOR TREATING WITHDRAWAL SYNDROMES USING NON-SEDATIVE DEXMEDETOMIDINE TRANSDERMAL COMPOSITIONS
  申请人：Teikoku Pharma USA, Inc.

  公开号：EP3054934A1

  公开（公告）日：2016-08-17
• METHODS AND DEVICES FOR SMOKING URGE RELIEF
  申请人：Fontem Holdings 1 B.V.

  公开号：EP3096636A1

  公开（公告）日：2016-11-30
• METHODS OF MANAGING PAIN USING DEXMEDETOMIDINE TRANSDERMAL DELIVERY DEVICES
  申请人：Teikoku Pharma USA, Inc.

  公开号：EP3532038A2

  公开（公告）日：2019-09-04
• Methods and Compositions for Treating Withdrawal Syndromes Using Non-Sedative Dexmedetomidine Transdermal Compositions
  申请人：Teikoku Pharma USA, Inc.

  公开号：US20150098983A1

  公开（公告）日：2015-04-09

  Aspects of the invention include methods of treating withdrawal syndrome by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a non-sedative amount of dexmedetomidine to a subject diagnosed as having withdrawal syndrome. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to treat withdrawal syndrome in the subject. Also provided are transdermal delivery devices configured to deliver a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.