2,4,6-Trimethyl-3,4-dihydropyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,4,6-Trimethyl-3,4-dihydropyridine
• 英文别名: 2,4,6-trimethyl-3,4-dihydropyridine
• 化学式: C₈H₁₃N
• 分子量: 123.2
• InChiKey: PAVBRYQFRKJGNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Coumarin-like cyclic compound as MEK inhibitor and use thereof
  申请人：CSTONE PHARMACEUTICALS

  公开号：US11021486B2

  公开（公告）日：2021-06-01

  Disclosed are a class of coumarin-like cyclic compounds as MEK inhibitors and pharmaceutical compositions comprising the compounds, and the use of same in the preparation of a drug for treating MEK-related diseases. Particularly disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof or tautomers thereof.

  公开了一类作为 MEK 抑制剂的香豆素类环状化合物和包含这些化合物的药物组合物，以及这些化合物在制备治疗 MEK 相关疾病的药物中的用途。特别公开的是如式（I）所示的化合物及其药学上可接受的盐或同系物。
• COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF
  申请人：CSTONE PHARMACEUTICALS

  公开号：US20200148695A1

  公开（公告）日：2020-05-14

  Disclosed are a class of coumarin-like cyclic compounds as MEK inhibitors and pharmaceutical compositions comprising the compounds, and the use of same in the preparation of a drug for treating MEK-related diseases. Particularly disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof or tautomers thereof.